TrpaC.17935.a

Chaperonin GroEL (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin-60) (Cpn60) (Common antigen) (CA) (TP4 antigen) (TP-4) (TPN60)

CENTER ID: TrpaC.17935.a
ORGANISM: Treponema pallidum subsp. pallidum Nichols
ASSOCIATED DISEASE: Syphilis
CURRENT STATUS: purified
COMMUNITY REQUEST: True
NIH RISK GROUP: 2
SELECT AGENT: False
NIH PRIORITY
pathogens category:		 unclassified

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Proteins

CENTER
REFERENCE ID		 DOMAIN/REGION
DESCRIPTION		 INFO AA
START		 AA
STOP		 ORDER
MATERIAL
TrpaC.17935.a.B1.PW39591 full length 1 544

External Resources

RESOURCE REFERENCE ID
UniProt: P23033

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "info" button next to the name of that material.
AA Sequence
MAKQLLFNEE ARKKLLSGVE QISSAVKVTL GPKGRNVLLE KGYGAPTVTK DGVSVAKEVE LEDPFENMGA QLLKEVATKT NDVAGDGTTT ATVLAYSMVR EGLKAVAAGM TPLELKRGMD KAVAIAVDDI KQNSKGIKSN EEVAHVASVS ANNDKEIGRI LASAIEKVGN DGVIDVDEAQ TMETVTEFVE GMQFDRGYIS SYFVTDRDRM ETVYENPYIL IYDKSISTMK DLLPLLEKIA QTGRPLLIIA EDVEGEALAT LVVNSLRGTL KTCAVKAPGF GDRRKEMLED IAILSGGQVI SEDLGLKLES ADIALLGQAK SVKVDKENTT IIDGSGKSKD IKDRIEQIKK QIEASTSDYD SEKLKERLAK LSGGVAVIKI GAVTEVEMKE KKHRVEDALN ATRAAIEEGI VAGGGLALIQ AAAALEKADL SGLTPDEAVG FKIVRRALEE PIRQISENAG IDGAVVAEKA KEKRGIGFDA SKMEWVDMIK VGIIDPAKVT RSALQNAASV SGLLLTTECA IAAIPEKSSS TPPAPDMGGM GGMY
NT Sequence
atggcgaacg aattgctgtt taatgaggaa gcccgcaaga agctgctttc cggggttgag cagatttcga gtgcggtgaa ggtaacgctt ggtcctaagg gtcgcaatgt cttgcttgaa aaagggtacg gggctcccac agtcacgaag gatggggttt ccgttgcgaa agaggttgag ctcgaagatc cgttcgagaa tatgggtgca cagcttttaa aagaggtggc tacgaagacg aacgacgtag ctggggatgg cacaactact gcgacggtat tggcgtattc gatggtgcgt gagggtctga aggcggttgc tgccggtatg acgccccttg agttgaagcg tggtatggat aaggcagttg cgattgcagt cgatgacatt aagcaaaatt ccaagggtat aaagagcaat gaagaagtcg ctcatgtagc gtcagtatct gcgaataacg acaaagagat tggaaggatt ctggcaagcg caatcgagaa ggtggggaat gacggggtca ttgacgttga cgaagcccag acaatggaaa cggtgacgga attcgttgaa gggatgcagt ttgatcgtgg gtacatctcg tcctacttcg tcactgaccg agataggatg gaaacggtgt atgaaaatcc ttacatcctt atctacgata agtccatctc gactatgaag gatttgcttc cgctactcga gaaaattgcg caaacaggtc gcccgctgct catcatagct gaggatgtcg aaggcgaagc actggctacg ctggtggtga atagtcttcg gggaacgctg aagacgtgtg cggtgaaggc tcccggtttc ggcgataggc gtaaagaaat gcttgaggat atcgcgattc tttcgggcgg tcaggtcatt tccgaggatt taggattgaa gctagagtcc gcggatattg cgctcttagg tcaggcaaag agcgtgaagg tagacaagga gaataccacg attattgacg ggtcgggtaa gtcgaaggat atcaaggatc gtatagagca gattaaaaag caaatagagg cctcgacttc agattatgac agtgagaagt tgaaggagcg cttggcaaag ctctctggtg gcgttgcagt tatcaaaatt ggtgcagtca ccgaagtgga aatgaaagag aagaagcacc gggttgaaga tgccttaaat gcgacacgtg cggcaataga ggaaggtatt gttgctggtg gtggtttagc gcttattcag gctgcggcgg cgctcgagaa agctgatttg agtggactga ctccagatga ggcggttggt tttaagattg tgcgtcgtgc tctcgaggag ccgatacgcc agatttcaga gaacgcgggt attgatggcg cagttgtggc agagaaggca aaggagaaac gtggcatcgg ttttgatgca tccaagatgg aatgggttga tatgattaag gtcgggatta tcgatccggc gaaggttaca cgttcagcac tacagaacgc ggcttcggtt tctgggcttt tgttgactac cgaatgtgca attgctgcaa ttgggcaaaa gagttcctct acaccgccag ctcctgacat gggaggtatg ggaggtatgt attga
Details for TrpaC.17935.a.B1.PW39591
PURIFICATION DATe: 6/24/2026
CONCENTRATION: 9.5mg/ml
OBSERVED MW: 59kDa
EXPRESSION LEVEL: Moderate Expression
PROTEIN PURIFICATION BUFFER: 25 mM HEPES pH 7.0, 500 mM NaCl, 5% Glycerol, 2 mM DTT, 0.025% Azide
EXPRESSION HOST: BL 21 (DE3) Rosetta
VIAL COUNT (approx.): 1
VIAL VOLUME: 100µl
PERCENT IDENTITY: data unavailable
PERCENT COVERAGE: data unavailable
Protocol Notes
notes unavailable
Validated AA Sequence
sequence unavailable
Validated NT Sequence
sequence unavailable
Expressed Protein Sequence
MAHHHHHHMA KQLLFNEEAR KKLLSGVEQI SSAVKVTLGP KGRNVLLEKG YGAPTVTKDG VSVAKEVELE DPFENMGAQL LKEVATKTND VAGDGTTTAT VLAYSMVREG LKAVAAGMTP LELKRGMDKA VAIAVDDIKQ NSKGIKSNEE VAHVASVSAN NDKEIGRILA SAIEKVGNDG VIDVDEAQTM ETVTEFVEGM QFDRGYISSY FVTDRDRMET VYENPYILIY DKSISTMKDL LPLLEKIAQT GRPLLIIAED VEGEALATLV VNSLRGTLKT CAVKAPGFGD RRKEMLEDIA ILSGGQVISE DLGLKLESAD IALLGQAKSV KVDKENTTII DGSGKSKDIK DRIEQIKKQI EASTSDYDSE KLKERLAKLS GGVAVIKIGA VTEVEMKEKK HRVEDALNAT RAAIEEGIVA GGGLALIQAA AALEKADLSG LTPDEAVGFK IVRRALEEPI RQISENAGID GAVVAEKAKE KRGIGFDASK MEWVDMIKVG IIDPAKVTRS ALQNAASVSG LLLTTECAIA AIPEKSSSTP PAPDMGGMGG MY
Full NT Sequence (Expression Vector + Insert)
TAATACGACT CACTATAGGG AGACCACAAC GGTTTCCCTC TAGAAATAAT TTTGTTTAAC TTTAAGAAGG AGATATACCA TGGCTCACCA CCACCACCAC CATATGGCGA ACGAATTGCT GTTTAATGAG GAAGCCCGCA AGAAGCTGCT TTCCGGGGTT GAGCAGATTT CGAGTGCGGT GAAGGTAACG CTTGGTCCTA AGGGTCGCAA TGTCTTGCTT GAAAAAGGGT ACGGGGCTCC CACAGTCACG AAGGATGGGG TTTCCGTTGC GAAAGAGGTT GAGCTCGAAG ATCCGTTCGA GAATATGGGT GCACAGCTTT TAAAAGAGGT GGCTACGAAG ACGAACGACG TAGCTGGGGA TGGCACAACT ACTGCGACGG TATTGGCGTA TTCGATGGTG CGTGAGGGTC TGAAGGCGGT TGCTGCCGGT ATGACGCCCC TTGAGTTGAA GCGTGGTATG GATAAGGCAG TTGCGATTGC AGTCGATGAC ATTAAGCAAA ATTCCAAGGG TATAAAGAGC AATGAAGAAG TCGCTCATGT AGCGTCAGTA TCTGCGAATA ACGACAAAGA GATTGGAAGG ATTCTGGCAA GCGCAATCGA GAAGGTGGGG AATGACGGGG TCATTGACGT TGACGAAGCC CAGACAATGG AAACGGTGAC GGAATTCGTT GAAGGGATGC AGTTTGATCG TGGGTACATC TCGTCCTACT TCGTCACTGA CCGAGATAGG ATGGAAACGG TGTATGAAAA TCCTTACATC CTTATCTACG ATAAGTCCAT CTCGACTATG AAGGATTTGC TTCCGCTACT CGAGAAAATT GCGCAAACAG GTCGCCCGCT GCTCATCATA GCTGAGGATG TCGAAGGCGA AGCACTGGCT ACGCTGGTGG TGAATAGTCT TCGGGGAACG CTGAAGACGT GTGCGGTGAA GGCTCCCGGT TTCGGCGATA GGCGTAAAGA AATGCTTGAG GATATCGCGA TTCTTTCGGG CGGTCAGGTC ATTTCCGAGG ATTTAGGATT GAAGCTAGAG TCCGCGGATA TTGCGCTCTT AGGTCAGGCA AAGAGCGTGA AGGTAGACAA GGAGAATACC ACGATTATTG ACGGGTCGGG TAAGTCGAAG GATATCAAGG ATCGTATAGA GCAGATTAAA AAGCAAATAG AGGCCTCGAC TTCAGATTAT GACAGTGAGA AGTTGAAGGA GCGCTTGGCA AAGCTCTCTG GTGGCGTTGC AGTTATCAAA ATTGGTGCAG TCACCGAAGT GGAAATGAAA GAGAAGAAGC ACCGGGTTGA AGATGCCTTA AATGCGACAC GTGCGGCAAT AGAGGAAGGT ATTGTTGCTG GTGGTGGTTT AGCGCTTATT CAGGCTGCGG CGGCGCTCGA GAAAGCTGAT TTGAGTGGAC TGACTCCAGA TGAGGCGGTT GGTTTTAAGA TTGTGCGTCG TGCTCTCGAG GAGCCGATAC GCCAGATTTC AGAGAACGCG GGTATTGATG GCGCAGTTGT GGCAGAGAAG GCAAAGGAGA AACGTGGCAT CGGTTTTGAT GCATCCAAGA TGGAATGGGT TGATATGATT AAGGTCGGGA TTATCGATCC GGCGAAGGTT ACACGTTCAG CACTACAGAA CGCGGCTTCG GTTTCTGGGC TTTTGTTGAC TACCGAATGT GCAATTGCTG CAATTGGGCA AAAGAGTTCC TCTACACCGC CAGCTCCTGA CATGGGAGGT ATGGGAGGTA TGTATTGAGT AAGATAGGAT CCGGCTGCTA ACAAAGCCCG AAAGGAAGCT GAGTTGGCTG CTGCCACCGC TGAGCAATAA CTAGCATAAC CCCTTGGGGC CTCTAAACGG GTCTTGAGGG GTTTTTTGCT GAAAGGAGGA ACTATATCCG GATATCCACA GGACGGGTGT GGTCGCCATG ATCGCGTAGT CGATAGTGGC TCCAAGTAGC GAAGCGAGCA GGACTGGGCG GCGGCCAAAG CGGTCGGACA GTGCTCCGAG AACGGGTGCG CATAGAAATT GCATCAACGC ATATAGCGCT AGCAGCACGC CATAGTGACT GGCGATGCTG TCGGAATGGA CGATATCCCG CAAGAGGCCC GGCAGTACCG GCATAACCAA GCCTATGCCT ACAGCATCCA GGGTGACGGT GCCGAGGATG ACGATGAGCG CATTGTTAGA TTTCATACAC GGTGCCTGAC TGCGTTAGCA ATTTAACTGT GATAAACTAC CGCATTAAAG CTTATCGATG ATAAGCTGTC AAACATGAGA ATTCTTGAAG ACGAAAGGGC CTCGTGATAC GCCTATTTTT ATAGGTTAAT GTCATGATAA TAATGGTTTC TTAGACGTCA GGTGGCACTT TTCGGGGAAA TGTGCGCGGA ACCCCTATTT GTTTATTTTT CTAAATACAT TCAAATATGT ATCCGCTCAT GAGACAATAA CCCTGATAAA TGCTTCAATA ATATTGAAAA AGGAAGAGTA TGAGTATTCA ACATTTCCGT GTCGCCCTTA TTCCCTTTTT TGCGGCATTT TGCCTTCCTG TTTTTGCTCA CCCAGAAACG CTGGTGAAAG TAAAAGATGC TGAAGATCAG TTGGGTGCAC GAGTGGGTTA CATCGAACTG GATCTCAACA GCGGTAAGAT CCTTGAGAGT TTTCGCCCCG AAGAACGTTT TCCAATGATG AGCACTTTTA AAGTTCTGCT ATGTGGCGCG GTATTATCCC GTGTTGACGC CGGGCAAGAG CAACTCGGTC GCCGCATACA CTATTCTCAG AATGACTTGG TTGAGTACTC ACCAGTCACA GAAAAGCATC TTACGGATGG CATGACAGTA AGAGAATTAT GCAGTGCTGC CATAACCATG AGTGATAACA CTGCGGCCAA CTTACTTCTG ACAACGATCG GAGGACCGAA GGAGCTAACC GCTTTTTTGC ACAACATGGG GGATCATGTA ACTCGCCTTG ATCGTTGGGA ACCGGAGCTG AATGAAGCCA TACCAAACGA CGAGCGTGAC ACCACGATGC CTGCAGCAAT GGCAACAACG TTGCGCAAAC TATTAACTGG CGAACTACTT ACTCTAGCTT CCCGGCAACA ATTAATAGAC TGGATGGAGG CGGATAAAGT TGCAGGACCA CTTCTGCGCT CGGCCCTTCC GGCTGGCTGG TTTATTGCTG ATAAATCTGG AGCCGGTGAG CGTGGGTCTC GCGGTATCAT TGCAGCACTG GGGCCAGATG GTAAGCCCTC CCGTATCGTA GTTATCTACA CGACGGGGAG TCAGGCAACT ATGGATGAAC GAAATAGACA GATCGCTGAG ATAGGTGCCT CACTGATTAA GCATTGGTAA CTGTCAGACC AAGTTTACTC ATATATACTT TAGATTGATT TAAAACTTCA TTTTTAATTT AAAAGGATCT AGGTGAAGAT CCTTTTTGAT AATCTCATGA CCAAAATCCC TTAACGTGAG TTTTCGTTCC ACTGAGCGTC AGACCCCGTA GAAAAGATCA AAGGATCTTC TTGAGATCCT TTTTTTCTGC GCGTAATCTG CTGCTTGCAA ACAAAAAAAC CACCGCTACC AGCGGTGGTT TGTTTGCCGG ATCAAGAGCT ACCAACTCTT TTTCCGAAGG TAACTGGCTT CAGCAGAGCG CAGATACCAA ATACTGTCCT TCTAGTGTAG CCGTAGTTAG GCCACCACTT CAAGAACTCT GTAGCACCGC CTACATACCT CGCTCTGCTA ATCCTGTTAC CAGTGGCTGC TGCCAGTGGC GATAAGTCGT GTCTTACCGG GTTGGACTCA AGACGATAGT TACCGGATAA GGCGCAGCGG TCGGGCTGAA CGGGGGGTTC GTGCACACAG CCCAGCTTGG AGCGAACGAC CTACACCGAA CTGAGATACC TACAGCGTGA GCTATGAGAA AGCGCCACGC TTCCCGAAGG GAGAAAGGCG GACAGGTATC CGGTAAGCGG CAGGGTCGGA ACAGGAGAGC GCACGAGGGA GCTTCCAGGG GGAAACGCCT GGTATCTTTA TAGTCCTGTC GGGTTTCGCC ACCTCTGACT TGAGCGTCGA TTTTTGTGAT GCTCGTCAGG GGGGCGGAGC CTATGGAAAA ACGCCAGCAA CGCGGCCTTT TTACGGTTCC TGGCCTTTTG CTGGCCTTTT GCTCACATGT TCTTTCCTGC GTTATCCCCT GATTCTGTGG ATAACCGTAT TACCGCCTTT GAGTGAGCTG ATACCGCTCG CCGCAGCCGA ACGACCGAGC GCAGCGAGTC AGTGAGCGAG GAAGCGGAAG AGCGCCTGAT GCGGTATTTT CTCCTTACGC ATCTGTGCGG TATTTCACAC CGCATATATG GTGCACTCTC AGTACAATCT GCTCTGATGC CGCATAGTTA AGCCAGTATA CACTCCGCTA TCGCTACGTG ACTGGGTCAT GGCTGCGCCC CGACACCCGC CAACACCCGC TGACGCGCCC TGACGGGCTT GTCTGCTCCC GGCATCCGCT TACAGACAAG CTGTGACCGT CTCCGGGAGC TGCATGTGTC AGAGGTTTTC ACCGTCATCA CCGAAACGCG CGAGGCAGCT GCGGTAAAGC TCATCAGCGT GGTCGTGAAG CGATTCACAG ATGTCTGCCT GTTCATCCGC GTCCAGCTCG TTGAGTTTCT CCAGAAGCGT TAATGTCTGG CTTCTGATAA AGCGGGCCAT GTTAAGGGCG GTTTTTTCCT GTTTGGTCAC TGATGCCTCC GTGTAAGGGG GATTTCTGTT CATGGGGGTA ATGATACCGA TGAAACGAGA GAGGATGCTC ACGATACGGG TTACTGATGA TGAACATGCC CGGTTACTGG AACGTTGTGA GGGTAAACAA CTGGCGGTAT GGATGCGGCG GGACCAGAGA AAAATCACTC AGGGTCAATG CCAGCGCTTC GTTAATACAG ATGTAGGTGT TCCACAGGGT AGCCAGCAGC ATCCTGCGAT GCAGATCCGG AACATAATGG TGCAGGGCGC TGACTTCCGC GTTTCCAGAC TTTACGAAAC ACGGAAACCG AAGACCATTC ATGTTGTTGC TCAGGTCGCA GACGTTTTGC AGCAGCAGTC GCTTCACGTT CGCTCGCGTA TCGGTGATTC ATTCTGCTAA CCAGTAAGGC AACCCCGCCA GCCTAGCCGG GTCCTCAACG ACAGGAGCAC GATCATGCGC ACCCGTGGCC AGGACCCAAC GCTGCCCGAG ATGCGCCGCG TGCGGCTGCT GGAGATGGCG GACGCGATGG ATATGTTCTG CCAAGGGTTG GTTTGCGCAT TCACAGTTCT CCGCAAGAAT TGATTGGCTC CAATTCTTGG AGTGGTGAAT CCGTTAGCGA GGTGCCGCCG GCTTCCATTC AGGTCGAGGT GGCCCGGCTC CATGCACCGC GACGCAACGC GGGGAGGCAG ACAAGGTATA GGGCGGCGCC TACAATCCAT GCCAACCCGT TCCATGTGCT CGCCGAGGCG GCATAAATCG CCGTGACGAT CAGCGGTCCA GTGATCGAAG TTAGGCTGGT AAGAGCCGCG AGCGATCCTT GAAGCTGTCC CTGATGGTCG TCATCTACCT GCCTGGACAG CATGGCCTGC AACGCGGGCA TCCCGATGCC GCCGGAAGCG AGAAGAATCA TAATGGGGAA GGCCATCCAG CCTCGCGTCG CGAACGCCAG CAAGACGTAG CCCAGCGCGT CGGCCGCCAT GCCGGCGATA ATGGCCTGCT TCTCGCCGAA ACGTTTGGTG GCGGGACCAG TGACGAAGGC TTGAGCGAGG GCGTGCAAGA TTCCGAATAC CGCAAGCGAC AGGCCGATCA TCGTCGCGCT CCAGCGAAAG CGGTCCTCGC CGAAAATGAC CCAGAGCGCT GCCGGCACCT GTCCTACGAG TTGCATGATA AAGAAGACAG TCATAAGTGC GGCGACGATA GTCATGCCCC GCGCCCACCG GAAGGAGCTG ACTGGGTTGA AGGCTCTCAA GGGCATCGGT CGACGCTCTC CCTTATGCGA CTCCTGCATT AGGAAGCAGC CCAGTAGTAG GTTGAGGCCG TTGAGCACCG CCGCCGCAAG GAATGGTGCA TGCAAGGAGA TGGCGCCCAA CAGTCCCCCG GCCACGGGGC CTGCCACCAT ACCCACGCCG AAACAAGCGC TCATGAGCCC GAAGTGGCGA GCCCGATCTT CCCCATCGGT GATGTCGGCG ATATAGGCGC CAGCAACCGC ACCTGTGGCG CCGGTGATGC CGGCCACGAT GCGTCCGGCG TAGAGGATCG AGATCTCGAT CCCGCGAAAT