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Seattle Structural Genomics Center for Infectious Disease

TrcrA.00198.b: iron superoxide dismutase, putative

Target Characteristics

from organism: Trypanosoma cruzi
most recent status: in PDB
center reference id: TrcrA.00198.b
is community request: True
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
TrcrA.00198.b.B1.GE35089 full length 1 233 GE35089
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
TrcrA.00198.b.B1.PS01521 full length 1 233

Structures

image of structure for 4H3E
4H3E
Deposited: 9/13/2012
Determination: XRay
Diffraction Image
Clone: TrcrA.00198.b.B1.GE35089
Protein: TrcrA.00198.b.B1.PS01521

Publications by SSGCID

Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures.
Anupama A, Cestari I, Davies DR, Edwards TE, Fairman JW, Moretti NS, Myler PJ, Phan IQ, Schenkman S, Shanmugam D, Stuart K
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. - 2015
volume 71, issue Pt 5, pages 615-21
PMID: 25961325; PMCID: PMC4427173
PDB: 4F2N, 4H3E, 4YET

External Resources

Resource Reference ID
EuPathDB: TritrypDB:Tc00.1047053509775.40
OrthoMCL: OG5_126676
RefSeq: XP_812157.1
UniProt: Q4DCQ3

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superoxide radicals degradation DETOX1-PWY 1.15.1.1
reactive oxygen species degradation DETOX1-PWY-1 1.15.1.1
ethylene biosynthesis III (microbes) PWY-6854 1.15.1.1

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MLRRAVNISI ARGRMALMSY ATLPDLLKPS GAPAELPKLG FNWKDGCAPV FSPRQMELHY TKHHKAYVDK LNALAGTTYD GKSIEEIILA VANDAEKKGL FNQAAQHFNH TFYFRCITPN GKAMPKSLES AVTAQFGSVE QFKDAFVQAG VNNFGSGWTW LCVDPSNKNQ LVIDNTSNAG CPLTKGLRPV LAVDVWEHAY YKDFENRRPD YLKEIWSVID WEFVAKMHAQ AIK

NT Sequence
atgttgagac gtgcggtgaa tatatccatt gccagagggc gcatggcgtt gatgagctac gcgacgctgc ctgacctttt aaaaccaagt ggcgccccgg ccgagttgcc caagttgggg tttaactgga aggatggatg tgcccctgtc ttcagcccgc gccagatgga attgcactac accaaacacc acaaggcgta tgtggacaaa ttaaatgcgc tggcagggac aacatacgat gggaagagca ttgaggagat tatccttgcg gtcgcaaatg acgccgagaa gaagggtctt ttcaaccaag ccgcacagca ttttaaccac accttttact tccgttgcat cacccctaat gggaaggcga tgccaaagtc ccttgagtct gctgttacgg cccagtttgg ttcggtggaa cagtttaaag atgcctttgt gcaggcaggg gtgaataact ttggctcggg ttggacgtgg ctgtgcgtgg acccgtcgaa taagaatcag ctcgttattg acaatacgag caacgccgga tgtcccttaa cgaagggact gcgccccgtc ctcgcagtgg atgtgtggga gcatgcgtac tacaaggact ttgaaaaccg ccggccggat tacttgaagg agatctggtc ggtcatcgac tgggagtttg ttgcaaagat gcatgcgcag gcaataaaat aa

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