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Seattle Structural Genomics Center for Infectious Disease

TrcrA.00019.a: prostaglandin f synthase

Target Characteristics

from organism: Trypanosoma cruzi
most recent status: in PDB
center reference id: TrcrA.00019.a
is community request: True
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
TrcrA.00019.a.B1.GE35081 full length 1 282 GE35081
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
TrcrA.00019.a.B1.PW35698 full length 1 282

Structures

image of structure for 4FZI
4FZI
Deposited: 7/6/2012
Determination: XRay
Diffraction Image
Clone: TrcrA.00019.a.B1.GE35081
Protein: TrcrA.00019.a.B1.PW35698
image of structure for 4GIE
4GIE
Deposited: 8/8/2012
Determination: XRay
Diffraction Image
Clone: TrcrA.00019.a.B1.GE35081
Protein: TrcrA.00019.a.B1.PW35698

Publications by SSGCID

Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.
Barnes SR, Edwards TE, Fairman JW, Lorimer DD, Moen SO, Myler PJ, Nakazawa-Hewitt S, Staker BL, Sullivan A, Van Voorhis WC
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. - 2015
volume 71, issue Pt 5, pages 609-14
PMID: 25945716; PMCID: PMC4361283
PDB: 4F40, 4FZI, 4G5D, 4GIE

External Resources

Resource Reference ID
EuPathDB: TritrypDB:Tc00.1047053511287.49
OrthoMCL: OG5_126583
RefSeq: XP_814362.1
UniProt: Q4DJ07

Enzyme & Pathway Information

Pathway Pathway ID EC Number
1.1.1.188

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MNCNYNCVTL HNSARMPQLG LGVWRAQDGA ETANAVRWAI EAGYRHIDTA CIYNNEKGVG QGIRESGVPR EEVWVTTKVW NSDQGYEKTL AAFERSRELL GLEYIDLYLI HWPGKKKFVD TWKALEKLYE EKKVRAIGVS NFEPHHLTEL FKSCKIRPMV NQVELHPLFQ QRTLREFCKQ HNIAITAWSP LGSGDRTGFL KNHVLGEIAK KHNKSPAQVV IRWDIQHGIV TIPKSTNKGR IQENFNVWDF KLTEEEMRQI DELNEDKRIG GHPDNFFPGG EE

NT Sequence
atgaattgca attacaactg tgtgacactc cataactccg cgcgaatgcc gcagcttggc ttgggtgttt ggcgggcaca ggacggagcc gagacggcga atgcggtccg gtgggcaatt gaggcaggct accgccacat cgacacggca tgcatctaca acaacgaaaa gggcgtgggg caggggatcc gcgaatcggg agtgccccgt gaggaggtgt gggtaacaac aaaagtatgg aattcagatc aaggatacga aaagacgctt gcggcctttg aacgcagccg tgagctgctc ggattggagt acattgatct ctacttaatt cactggccgg ggaagaagaa gtttgttgac acatggaaag cattggagaa gctctacgag gagaagaagg tgcgggccat tggcgtttcc aactttgagc cacaccacct cacggagctt tttaaaagct gcaaaattcg gccgatggtc aaccaagtgg agctgcaccc gctgttccaa cagcgtactt tgcgggagtt ctgcaagcaa cacaacattg ccatcacagc ctggtctccg cttggcagcg gggaccggac gggttttctg aagaatcacg tgctggggga gattgccaag aagcacaata aatccccggc gcaggttgtc atccgctggg acattcagca cggtatcgtg acaattccca agtccacaaa taaggggcgc attcaagaaa actttaatgt ttgggacttt aaacttacgg aagaggagat gcgtcaaatc gatgaactca acgaggataa acgcatcggc ggacaccctg ataatttttt ccctggtgga gaggagtga

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