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TrbrA.00438.a: nucleoside diphosphate kinase b

Target Characteristics

from organism: Trypanosoma brucei TREU927
most recent status: in PDB
center reference id: TrbrA.00438.a
is community request: True
associated disease: African trypanosomiasis (African Sleeping Sickness)
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
TrbrA.00438.a.B1.GE34488 full length 1 153 GE34488
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
TrbrA.00438.a.B1.PS01459 full length 1 153

Structures

image of structure for 4F36
4F36
Deposited: 5/8/2012
Determination: XRay
Diffraction Image
Clone: TrbrA.00438.a.B1.GE34488
Protein: TrbrA.00438.a.B1.PS01459
image of structure for 4F4A
4F4A
Deposited: 5/10/2012
Determination: XRay
Diffraction Image
Clone: TrbrA.00438.a.B1.GE34488
Protein: TrbrA.00438.a.B1.PS01459
image of structure for 4FKX
4FKX
Deposited: 6/13/2012
Determination: XRay
Diffraction Image
Clone: TrbrA.00438.a.B1.GE34488
Protein: TrbrA.00438.a.B1.PS01459
image of structure for 4FKY
4FKY
Deposited: 6/13/2012
Determination: XRay
Diffraction Image
Clone: TrbrA.00438.a.B1.GE34488
Protein: TrbrA.00438.a.B1.PS01459

External Resources

Resource Reference ID
EuPathDB: TritrypDB:Tb11.01.7800
OrthoMCL: OG5_126708
RefSeq: XP_829670.1
UniProt: Q381H3

Enzyme & Pathway Information

Pathway Pathway ID EC Number
superpathway of purine nucleotides de novo biosynthesis II DENOVOPURINE2-PWY 2.7.4.6
ppGpp biosynthesis PPGPPMET-PWY 2.7.4.6
superpathway of histidine, purine, and pyrimidine biosynthesis PRPP-PWY 2.7.4.6
superpathway of pyrimidine ribonucleotides de novo biosynthesis PWY0-162 2.7.4.6
salvage pathways of pyrimidine ribonucleotides PWY0-163 2.7.4.6
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) PWY0-166 2.7.4.6
pyrimidine ribonucleotides interconversion PWY-5687 2.7.4.6
superpathway of guanosine nucleotides de novo biosynthesis II PWY-6125 2.7.4.6
superpathway of adenosine nucleotides de novo biosynthesis II PWY-6126 2.7.4.6
pyrimidine deoxyribonucleotides de novo biosynthesis III PWY-6545 2.7.4.6
superpathway of purine nucleotide salvage PWY66-409 2.7.4.6
UTP and CTP de novo biosynthesis PWY-7176 2.7.4.6
pyrimidine deoxyribonucleotides de novo biosynthesis I PWY-7184 2.7.4.6
pyrimidine deoxyribonucleotides de novo biosynthesis II PWY-7187 2.7.4.6
superpathway of pyrimidine ribonucleosides salvage PWY-7196 2.7.4.6
pyrimidine deoxyribonucleotide phosphorylation PWY-7197 2.7.4.6
pyrimidine deoxyribonucleotides de novo biosynthesis IV PWY-7198 2.7.4.6
superpathway of pyrimidine deoxyribonucleoside salvage PWY-7200 2.7.4.6
CMP phosphorylation PWY-7205 2.7.4.6
superpathway of pyrimidine nucleobases salvage PWY-7208 2.7.4.6
pyrimidine deoxyribonucleotides biosynthesis from CTP PWY-7210 2.7.4.6
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis PWY-7211 2.7.4.6
adenosine deoxyribonucleotides de novo biosynthesis II PWY-7220 2.7.4.6
guanosine ribonucleotides de novo biosynthesis PWY-7221 2.7.4.6
guanosine deoxyribonucleotides de novo biosynthesis II PWY-7222 2.7.4.6
purine deoxyribonucleosides salvage PWY-7224 2.7.4.6
guanosine deoxyribonucleotides de novo biosynthesis I PWY-7226 2.7.4.6
adenosine deoxyribonucleotides de novo biosynthesis PWY-7227 2.7.4.6
superpathway of guanosine nucleotides de novo biosynthesis I PWY-7228 2.7.4.6
superpathway of adenosine nucleotides de novo biosynthesis I PWY-7229 2.7.4.6
superpathway of purine nucleotides de novo biosynthesis I PWY-841 2.7.4.6

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MPSERTFIAV KPDGVQRNLV GEIIKRFENK GYKLVGLKLL QPTEEQAKQH YIDLASKPFY SGLVSYFSSG PIVGMVWEGL GVVKGGRVLL GATNPADSLP GTIRGDFAVD VGRNVCHGSD SVESAKREIA FWFKAEELVS WTSHSVKQIY ERA

NT Sequence
atgcccagcg agcggacctt cattgcagtc aaacccgatg gcgtgcagcg taatctcgtg ggagaaatca tcaagcgctt cgagaacaag ggctacaaac ttgttggtct caaacttctc cagcccactg aggaacaagc caagcagcac tacattgatc tcgcatcgaa acccttctac agtggccttg tgtcgtactt ttcctctggc cctatcgtcg gtatggtgtg ggagggcctc ggtgttgtaa agggcggccg tgtgcttttg ggcgcaacga accccgcaga ctcgctccct ggcaccattc gtggtgactt cgccgtggat gttggccgca atgtgtgcca tgggtccgac agcgtggaaa gcgccaaacg cgaaatcgcg ttctggttca aggcggagga gctggtaagc tggacgtccc actccgtcaa gcaaatttat gaaagggcat aa

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