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Target Status
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Plasmodium
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PlviB.18219.a

PlviB.18219.a: Glycylpeptide N-tetradecanoyltransferase, N-myristoyltransferase (NMT)

Target Characteristics

from organism: Plasmodium vivax Salvador I
most recent status: in PDB
center reference id: PlviB.18219.a
is community request: True
associated disease: Malaria
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:		 unclassified

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Structures

image of structure for 5V0W
5V0W
Deposited: 2/28/2017
Determination: XRay
Diffraction Image
Clone: PlviB.18219.a.FR2.GE40922
Protein: PlviB.18219.a.FR2.PS38092
image of structure for 5V0X
5V0X
Deposited: 2/28/2017
Determination: XRay
Diffraction Image
Clone: PlviB.18219.a.FR2.GE40922
Protein: PlviB.18219.a.FR2.PS38092
image of structure for 6B1L
6B1L
Deposited: 9/18/2017
Determination: XRay
Diffraction Image
Clone: PlviB.18219.a.FR2.GE40922
Protein: PlviB.18219.a.FR2.PS38192
image of structure for 6MAY
6MAY
Deposited: 8/29/2018
Determination: XRay
Diffraction Image
Clone: PlviB.18219.a.FR21.GE41600
Protein: PlviB.18219.a.FR21.PS38348
image of structure for 6MAZ
6MAZ
Deposited: 8/29/2018
Determination: XRay
Diffraction Image
Clone: PlviB.18219.a.FR21.GE41600
Protein: PlviB.18219.a.FR21.PS38348
image of structure for 6MB0
6MB0
Deposited: 8/29/2018
Determination: XRay
Diffraction Image
Clone: PlviB.18219.a.FR21.GE41600
Protein: PlviB.18219.a.FR21.PS38348
image of structure for 6MB1
6MB1
Deposited: 8/29/2018
Determination: XRay
Diffraction Image
Clone: PlviB.18219.a.FR2.GE40922
Protein: PlviB.18219.a.FR2.PS38393
image of structure for 6NXG
6NXG
Deposited: 2/8/2019
Determination: XRay
Diffraction Image
Clone: PlviB.18219.a.FR21.GE41600
Protein: PlviB.18219.a.FR21.PS38348

Publications by SSGCID

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors
Lyons-Abbott S, Myler P, Staker B, Reers A, Mayclin SJ, Schlott A, Coburn-Flynn O, Bell A, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Chung CW, Fidock DA, Tate E, Holder A
Cell Chem Biol - 2019
volume S2451-9456, issue 19, pages 30111-4
PMID: 31080074; PMCID: PMC6437504
PDB: 6MAY, 6MAZ, 6MB0, 6MB1
Identification of selective inhibitors of Plasmodium N-myristoyltransferase by high throughput screening
Lyons-Abbott S, Myler PJ, Staker BL, Reers A, Charter D, Chung CW, Harupa A, De Las Heras L, Colmenarejo G, Caballero I, Fernández-Menéndez R, Calderón F, Palomo S, Rodríguez-Miquel B, Berlanga M, Herreros-Avilés E, Fernández-Álvaro E, Kaushansky A
J. Med. Chem. - 2019
volume 63, issue 2, pages 591-600
PMID: 31850752
PDB: 6NXG

External Resources

Resource Reference ID
EuPathDB: PlasmoDB:PVX_085815
RefSeq: XP_001616826.1
UniProt: A5K1A2

Enzyme & Pathway Information

Pathway Pathway ID EC Number
2.3.1.97

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MNDDNKEFSG RDIYQLIKNA KDKIKIDYKF WYTQPVPKIN DEFNESVNEP FISDNKVEDV RKDEYKLPPG YSWYVCDVKD EKDRSEIYTL LTDNYVEDDD NIFRFNYSAE FLLWALTSPN YLKTWHIGVK YDASNKLIGF ISAIPTDICI HKRTIKMAEV NFLCVHKTLR SKRLAPVLIK EITRRINLEN IWQAIYTAGV YLPKPVSDAR YYHRSINVKK LIEIGFSSLN SRLTMSRAIK LYRVEDTLNI KNMRLMKKKD VEGVHKLLGS YLEQFNLYAV FTKEEIAHWF LPIENVIYTY VNEENGKIKD MISFYSLPSQ ILGNDKYSTL NAAYSFYNVT TTATFKQLMQ DAILLAKRNN FDVFNALEVM QNKSVFEDLK FGEGDGSLKY YLYNWKCASF APAHVGIVLL

NT Sequence
atgaacgatg ataataagga attttccggg agagacatat accagctaat aaaaaatgcc aaggataaga tcaaaatcga ttacaagttt tggtacacgc agcccgtgcc caaaataaat gacgagttta acgaatcggt gaacgagcca ttcataagtg acaacaaagt ggaggatgtc cgaaaggatg agtacaaact gccgccggga tactcctggt acgtgtgcga cgtgaaggac gaaaaggacc ggagcgaaat ttacacgctg ctcacagaca actacgtaga agacgacgac aacatcttcc ggttcaacta ctctgcggag tttttactat gggctttgac ctctccaaat tatttaaaaa cgtggcacat tggcgtaaag tatgacgcgt ctaataagct aatcggattt ataagcgcca tcccgacgga tatatgcatt cataagagaa cgatcaaaat ggcggaagtt aatttcttat gcgtccacaa aactttgagg tcgaaacggc tagctccagt cttaattaaa gaaataacga ggaggatcaa tttagaaaac atatggcaag ctatctacac agcaggggtt tatttgccca agccagtaag tgacgcaagg tattaccaca gatctattaa tgtgaaaaaa ttgatcgaaa taggtttttc ctccctaaac tctagactaa ccatgagtag ggccattaaa ctgtatagag ttgaggatac attaaatata aaaaatatga gacttatgaa gaagaaggac gtcgaagggg tacataaatt gttgggcagt tacttagagc aatttaattt atatgctgtt tttacgaaag aagaaattgc ccactggttt cttcccatcg aaaatgttat ttatacttat gtgaatgaag aaaatggaaa aataaaagac atgatttctt tttattcttt accgtctcaa attttgggaa atgataagta tagcacgttg aatgctgcct actcctttta caacgtcacc acgacagcca cgttcaaaca gttgatgcag gatgccattc tcctggccaa gaggaacaac tttgacgtgt ttaacgcgct ggaagtgatg cagaacaaat ccgtctttga ggacttgaag ttcggcgagg gcgacgggtc gctcaagtac tacctctaca actggaagtg cgcctccttc gcccccgcgc acgtcggcat tgtgctgctc tga

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