PlviB.18219.a
Glycylpeptide N-tetradecanoyltransferase, N-myristoyltransferase (NMT)
| CENTER ID: | PlviB.18219.a |
| ORGANISM: | Plasmodium vivax Salvador I |
| ASSOCIATED DISEASE: | Malaria |
| CURRENT STATUS: | in PDB |
| COMMUNITY REQUEST: | True |
| NIH RISK GROUP: | 2 |
| SELECT AGENT: | False |
| NIH PRIORITY pathogens category: |
unclassified |
Ordering Clones & Proteins
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Structures
5V0W
DEPOSITED: 2/28/2017
DETERMINATION: XRay
CLONE: PlviB.18219.a.FR2.GE40922
PROTEIN: PlviB.18219.a.FR2.PS38092
5V0X
DEPOSITED: 2/28/2017
DETERMINATION: XRay
CLONE: PlviB.18219.a.FR2.GE40922
PROTEIN: PlviB.18219.a.FR2.PS38092
6B1L
DEPOSITED: 9/18/2017
DETERMINATION: XRay
CLONE: PlviB.18219.a.FR2.GE40922
PROTEIN: PlviB.18219.a.FR2.PS38192
6MAY
DEPOSITED: 8/29/2018
DETERMINATION: XRay
CLONE: PlviB.18219.a.FR21.GE41600
PROTEIN: PlviB.18219.a.FR21.PS38348
6MAZ
DEPOSITED: 8/29/2018
DETERMINATION: XRay
CLONE: PlviB.18219.a.FR21.GE41600
PROTEIN: PlviB.18219.a.FR21.PS38348
6MB0
DEPOSITED: 8/29/2018
DETERMINATION: XRay
CLONE: PlviB.18219.a.FR21.GE41600
PROTEIN: PlviB.18219.a.FR21.PS38348
6MB1
DEPOSITED: 8/29/2018
DETERMINATION: XRay
CLONE: PlviB.18219.a.FR2.GE40922
PROTEIN: PlviB.18219.a.FR2.PS38393
6NXG
DEPOSITED: 2/8/2019
DETERMINATION: XRay
CLONE: PlviB.18219.a.FR21.GE41600
PROTEIN: PlviB.18219.a.FR21.PS38348
8FBQ
DEPOSITED: 11/29/2022
DETERMINATION: XRay
CLONE: PlviB.18219.a.FR2.GE40922
PROTEIN: PlviB.18219.a.FR2.PS38287
Publications by SSGCID
Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors
Lyons-Abbott S, Myler P, Staker B, Reers A, Mayclin SJ, Schlott A, Coburn-Flynn O, Bell A, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Chung CW, Fidock DA, Tate E, Holder A
Cell Chem Biol - 2019
volume S2451-9456, issue 19, pages 30111-4
PMID: 31080074; PMCID: PMC6437504
Identification of selective inhibitors of Plasmodium N-myristoyltransferase by high throughput screening
Lyons-Abbott S, Myler PJ, Staker BL, Reers A, Charter D, Chung CW, Harupa A, De Las Heras L, Colmenarejo G, Caballero I, Fernández-Menéndez R, Calderón F, Palomo S, Rodríguez-Miquel B, Berlanga M, Herreros-Avilés E, Fernández-Álvaro E, Kaushansky A
J. Med. Chem. - 2019
volume 63, issue 2, pages 591-600
PMID: 31850752
PDB:
6NXG
Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts
Myler PJ, Sankaran B, Staker BL, Kaushansky A, Zigweid R, Fenwick MK, Glennon EKK, Rodriguez-Hernandez D, Grotli M, Vijayan K, Roobsoong W, Sattabongkot J, Sunnerhagen P
Nat Commun - 2023
volume 14, issue 1, pages 5408
PMID: 37669940; PMCID: PMC10480161
PDB:
8FBQ
Structure of Plasmodium vivax N-myristoyl transferase with inhibitor IMP-1088 - exploring an NMT inhibitor for antimalarial therapy
Abendroth J, Edwards TE, Lorimer DD, Myler PJ, Staker BL, Subramanian S, Reers A, Mayclin SJ, Hammerson B, Bell A, Tate E, Chakafana G, Bolling C, Mendez A, Taylor S, Makumire S, Asojo OA
Acta Crystallogr F Struct Biol Commun - 2024
volume 81, issue Pt 1, pages 1-10
PMID: 39655507; PMCID: PMC11701927
Ternary structure of Plasmodium vivax N-myristoyl transferase (PvNMT) with myristoyl-CoA and inhibitor IMP-0001173
Dranow DM, Edwards TE, Myler PJ, Staker BL, Subramanian S, Reers A, Asojo OA, Bell A, Tate E, Zigweid R, Chakafana G, Bolling C, Mendez A, Taylor S, Makumire S
Acta Crystallogr F Struct Biol Commun - 2024
volume 80, issue 10, pages 269-277
PMID: 39291304; PMCID: PMC11448930
PDB:
6B1L
Exploring Subsite Selectivity within Plasmodium vivax N-Myristoyltransferase Using Pyrazole-Derived Inhibitors
Myler PJ, Sankaran B, Staker BL, Kaushansky A, Zigweid R, Rodriguez-Hernandez D, Grotli M, Sunnerhagen P, Fenwick MK
J. Med. Chem. - 2024
volume 67, issue 9, pages 7312-7329
PMID: 38680035; PMCID: PMC11089503
External Resources
| RESOURCE | REFERENCE ID |
|---|---|
| EuPathDB: | PlasmoDB:PVX_085815 |
| RefSeq: | XP_001616826.1 |
| UniProt: | A5K1A2 |
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols.
To find the specific sequence of any material you may have ordered, click on the "info" button next to the name of that material.
AA Sequence
MNDDNKEFSG RDIYQLIKNA KDKIKIDYKF WYTQPVPKIN DEFNESVNEP FISDNKVEDV RKDEYKLPPG YSWYVCDVKD EKDRSEIYTL LTDNYVEDDD NIFRFNYSAE FLLWALTSPN YLKTWHIGVK YDASNKLIGF ISAIPTDICI HKRTIKMAEV NFLCVHKTLR SKRLAPVLIK EITRRINLEN IWQAIYTAGV YLPKPVSDAR YYHRSINVKK LIEIGFSSLN SRLTMSRAIK LYRVEDTLNI KNMRLMKKKD VEGVHKLLGS YLEQFNLYAV FTKEEIAHWF LPIENVIYTY VNEENGKIKD MISFYSLPSQ ILGNDKYSTL NAAYSFYNVT TTATFKQLMQ DAILLAKRNN FDVFNALEVM QNKSVFEDLK FGEGDGSLKY YLYNWKCASF APAHVGIVLL
NT Sequence
atgaacgatg ataataagga attttccggg agagacatat accagctaat aaaaaatgcc aaggataaga tcaaaatcga ttacaagttt tggtacacgc agcccgtgcc caaaataaat gacgagttta acgaatcggt gaacgagcca ttcataagtg acaacaaagt ggaggatgtc cgaaaggatg agtacaaact gccgccggga tactcctggt acgtgtgcga cgtgaaggac gaaaaggacc ggagcgaaat ttacacgctg ctcacagaca actacgtaga agacgacgac aacatcttcc ggttcaacta ctctgcggag tttttactat gggctttgac ctctccaaat tatttaaaaa cgtggcacat tggcgtaaag tatgacgcgt ctaataagct aatcggattt ataagcgcca tcccgacgga tatatgcatt cataagagaa cgatcaaaat ggcggaagtt aatttcttat gcgtccacaa aactttgagg tcgaaacggc tagctccagt cttaattaaa gaaataacga ggaggatcaa tttagaaaac atatggcaag ctatctacac agcaggggtt tatttgccca agccagtaag tgacgcaagg tattaccaca gatctattaa tgtgaaaaaa ttgatcgaaa taggtttttc ctccctaaac tctagactaa ccatgagtag ggccattaaa ctgtatagag ttgaggatac attaaatata aaaaatatga gacttatgaa gaagaaggac gtcgaagggg tacataaatt gttgggcagt tacttagagc aatttaattt atatgctgtt tttacgaaag aagaaattgc ccactggttt cttcccatcg aaaatgttat ttatacttat gtgaatgaag aaaatggaaa aataaaagac atgatttctt tttattcttt accgtctcaa attttgggaa atgataagta tagcacgttg aatgctgcct actcctttta caacgtcacc acgacagcca cgttcaaaca gttgatgcag gatgccattc tcctggccaa gaggaacaac tttgacgtgt ttaacgcgct ggaagtgatg cagaacaaat ccgtctttga ggacttgaag ttcggcgagg gcgacgggtc gctcaagtac tacctctaca actggaagtg cgcctccttc gcccccgcgc acgtcggcat tgtgctgctc tga