MysmA.01263.c
Isovaleryl-CoA dehydrogenase
| CENTER ID: | MysmA.01263.c |
| ORGANISM: | Mycobacterium smegmatis ATCC 700084 / mc(2)155 |
| ASSOCIATED DISEASE: | |
| CURRENT STATUS: | in PDB |
| COMMUNITY REQUEST: | False |
| NIH RISK GROUP: | 2 |
| SELECT AGENT: | False |
| NIH PRIORITY pathogens category: |
IIIC |
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Proteins
| CENTER REFERENCE ID |
DOMAIN/REGION DESCRIPTION |
INFO | AA START |
AA STOP |
ORDER MATERIAL |
|---|---|---|---|---|---|
| MysmA.01263.c.A1.PS00661 | Full length( MysmA.01263.c ) | 1 | 384 |
Structures
4IV6
DEPOSITED: 1/22/2013
DETERMINATION: XRay
CLONE: MysmA.01263.c.A1.GE28899
PROTEIN: MysmA.01263.c.A1.PS00661
Publications by SSGCID
Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB:
3MOY,
3MYB,
3LLS,
3GVG,
3MPZ,
3NF4,
3ICO,
3H81,
3HWK,
3NDN,
3KHP,
3GVC,
3HWI,
3H7F,
3HE2,
3GWC,
3HZG,
3NG3,
3OI9,
3OC7,
3NDO,
3OME,
3NJD,
3NWO,
3O0M,
3O38,
3OC6,
3OL3,
3OL4,
3OEC,
3QXZ,
3QUV,
3PPI,
3P4I,
3Q1T,
3PXX,
3QHA,
3P5M,
3R0O,
3P85,
3QLJ,
3QH4,
3QRE,
3QMJ,
3QKA,
3QDF,
3QK8,
3R1I,
3QBP,
3QXI,
3QIV,
3P0T,
3PZY,
3PGX,
3QYR,
3P4T,
3QUA,
3P2Y,
3Q8N,
3OKS,
3PK0,
3PE8,
3TDE,
3R7K,
3SLL,
3R9Q,
3RR6,
3R6O,
3R8C,
4DIE,
4DXL,
4ED4,
4EMD,
3TCR,
3R9R,
4EYE,
3TX2,
3S55,
3RIH,
3RRP,
3SWX,
3RSI,
3TRR,
3TAV,
3RD7,
3SVK,
3R1J,
3UVE,
3T7C,
3R9S,
3S82,
3R2N,
4DI1,
3U0A,
3TZQ,
4F3W,
3SBX,
4DQ8,
3RFQ,
3R6H,
3R4T,
3TZU,
3RR2,
3SWT,
4F47,
3RV2,
3R9P,
3RRV,
3TJR,
3RD5,
3SX2,
3TSC,
3R9T,
3TLF,
3U0B,
3R20,
3UCX,
4EGF,
3RD8,
3SWO,
3SF6,
3SVT,
3TL3,
4EGE,
3T3W,
4EO9,
4HR3,
4FFC,
4GK6,
4IZ9,
4LGV,
5EJ2,
4KAM,
4O2D,
4IJN,
4J5I,
4IV6,
4I1Y,
4HDT
External Resources
| RESOURCE | REFERENCE ID |
|---|---|
| BV-BRC: | fig|246196.19.peg.1968 |
| RefSeq: | YP_886355.1 |
| UniProt: | A0QTW7 |
Orthologues for Rv0215c
| Species | % Identity | % Coverage | Clones | Proteins | Structures |
|---|---|---|---|---|---|
| thermoresistibile | 85 | 100 | 1 | 1 | 0 |
| smegmatis | 72 | 99 | 0 | 2 | 1 |
| thermoresistibile | 32 | 98 | 0 | 0 | 0 |
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols.
To find the specific sequence of any material you may have ordered, click on the "info" button next to the name of that material.
AA Sequence
MALTAEEETI VKTVHDFVEK QVKPVVRELE HANTYPEELI ETMKEIGIFG LAIPEPYGFG AVSMPCYVQV AEELARGWMS LAGAMGGHTV VSKLLLLFGT EEQKQKYLPR MATGELRATM ALTEPGGGSD LQAMRTVARR DGDDYVINGS KTWISNARRS DLVALMCKTD PDAQPAHKGV SILLVEKVPG FDVSRDLPKL GYKGVESCEL NFTDARVPVS SLLGDDEGRG FAQMMKGLEV GRLQVAARAT GVARAAFEDA LRYSQERESF GKPIWQHQSV GNMLADMGTK LYAARSLLLS AAEKFDAGQR CDMEAGMAKL FASETAMQIA LDAVRVHGGY GYSTEYDVER YFRDAPLMIV GEGTNEIQRN VIAKQLVARG GLDI
NT Sequence
ATGGCGCTGA CGGCCGAAGA GGAAACCATC GTCAAGACGG TGCACGATTT CGTCGAGAAG CAGGTCAAAC CGGTGGTACG GGAGTTGGAG CACGCCAACA CCTATCCCGA AGAGCTGATC GAGACGATGA AGGAGATCGG TATCTTCGGG CTCGCGATCC CGGAGCCGTA CGGGTTCGGG GCGGTGTCCA TGCCGTGTTA CGTGCAGGTC GCCGAGGAAC TGGCCAGGGG CTGGATGAGC CTGGCCGGCG CGATGGGCGG CCACACCGTG GTGTCGAAGC TGCTGTTGCT GTTCGGCACC GAGGAGCAGA AGCAGAAATA CCTGCCGCGG ATGGCCACCG GTGAACTGCG CGCCACGATG GCGCTCACCG AACCCGGTGG CGGGTCGGAT CTGCAGGCCA TGCGCACCGT CGCGCGCCGG GACGGCGACG ACTACGTGAT CAACGGCAGC AAGACCTGGA TCTCCAACGC GCGGCGCTCG GATCTGGTGG CGCTGATGTG CAAGACCGAT CCCGACGCGC AGCCCGCACA CAAGGGTGTG TCGATCCTCC TGGTGGAGAA GGTGCCCGGC TTCGACGTGT CACGCGACCT ACCCAAGCTG GGCTACAAGG GCGTGGAGAG CTGCGAGCTC AACTTCACCG ACGCCCGGGT TCCGGTCTCC TCGCTGCTCG GCGACGACGA GGGCCGTGGG TTCGCGCAGA TGATGAAAGG CCTGGAGGTG GGCCGGTTGC AGGTCGCGGC GCGGGCAACG GGCGTGGCGC GTGCGGCGTT CGAGGATGCG CTGCGGTACT CCCAGGAGCG GGAGAGCTTC GGCAAGCCGA TCTGGCAACA CCAGTCGGTC GGAAACATGT TGGCCGACAT GGGAACCAAG CTGTACGCAG CGCGCTCGCT GCTGCTCAGT GCGGCCGAGA AGTTCGACGC GGGGCAACGC TGTGACATGG AGGCCGGCAT GGCCAAGCTG TTCGCGTCGG AGACCGCGAT GCAGATCGCA CTGGACGCCG TACGCGTGCA CGGGGGCTAC GGCTATTCCA CCGAGTACGA CGTCGAACGT TACTTCCGCG ATGCGCCACT GATGATCGTC GGCGAGGGCA CCAACGAGAT CCAGCGCAAC GTGATCGCCA AACAACTCGT CGCGCGCGGC GGTCTCGACA TC
Details for MysmA.01263.c.A1.PS00661
| PURIFICATION DATe: | 7/7/2010 |
| CONCENTRATION: | 63.61mg/ml |
| OBSERVED MW: | data unavailable |
| EXPRESSION LEVEL: | Moderate Expression |
| PROTEIN PURIFICATION BUFFER: | 20 mM HEPES, pH 7.0, 300 mM NaCl, 5% glycerol and 1 mM TCEP |
| EXPRESSION HOST: | data unavailable |
| VIAL COUNT (approx.): | 8 |
| VIAL VOLUME: | 200µl |
| PERCENT IDENTITY: | data unavailable |
| PERCENT COVERAGE: | data unavailable |
Protocol Notes
notes unavailable
Validated AA Sequence
sequence unavailable
Validated NT Sequence
sequence unavailable
Expressed Protein Sequence
MAHHHHHHMG TLEAQTQGPG SMALTAEEET IVKTVHDFVE KQVKPVVREL EHANTYPEEL IETMKEIGIF GLAIPEPYGF GAVSMPCYVQ VAEELARGWM SLAGAMGGHT VVSKLLLLFG TEEQKQKYLP RMATGELRAT MALTEPGGGS DLQAMRTVAR RDGDDYVING SKTWISNARR SDLVALMCKT DPDAQPAHKG VSILLVEKVP GFDVSRDLPK LGYKGVESCE LNFTDARVPV SSLLGDDEGR GFAQMMKGLE VGRLQVAARA TGVARAAFED ALRYSQERES FGKPIWQHQS VGNMLADMGT KLYAARSLLL SAAEKFDAGQ RCDMEAGMAK LFASETAMQI ALDAVRVHGG YGYSTEYDVE RYFRDAPLMI VGEGTNEIQR NVIAKQLVAR GGLDI
Full NT Sequence (Expression Vector + Insert)
TTCTTGAAGA CGAAAGGGCC TCGTGATACG CCTATTTTTA TAGGTTAATG TCATGATAAT AATGGTTTCT TAGACGTCAG GTGGCACTTT TCGGGGAAAT GTGCGCGGAA CCCCTATTTG TTTATTTTTC TAAATACATT CAAATATGTA TCCGCTCATG AGACAATAAC CCTGATAAAT GCTTCAATAA TATTGAAAAA GGAAGAGTAT GAGTATTCAA CATTTCCGTG TCGCCCTTAT TCCCTTTTTT GCGGCATTTT GCCTTCCTGT TTTTGCTCAC CCAGAAACGC TGGTGAAAGT AAAAGATGCT GAAGATCAGT TGGGTGCACG AGTGGGTTAC ATCGAACTGG ATCTCAACAG CGGTAAGATC CTTGAGAGTT TTCGCCCCGA AGAACGTTTT CCAATGATGA GCACTTTTAA AGTTCTGCTA TGTGGCGCGG TATTATCCCG TGTTGACGCC GGGCAAGAGC AACTCGGTCG CCGCATACAC TATTCTCAGA ATGACTTGGT TGAGTACTCA CCAGTCACAG AAAAGCATCT TACGGATGGC ATGACAGTAA GAGAATTATG CAGTGCTGCC ATAACCATGA GTGATAACAC TGCGGCCAAC TTACTTCTGA CAACGATCGG AGGACCGAAG GAGCTAACCG CTTTTTTGCA CAACATGGGG GATCATGTAA CTCGCCTTGA TCGTTGGGAA CCGGAGCTGA ATGAAGCCAT ACCAAACGAC GAGCGTGACA CCACGATGCC TGCAGCAATG GCAACAACGT TGCGCAAACT ATTAACTGGC GAACTACTTA CTCTAGCTTC CCGGCAACAA TTAATAGACT GGATGGAGGC GGATAAAGTT GCAGGACCAC TTCTGCGCTC GGCCCTTCCG GCTGGCTGGT TTATTGCTGA TAAATCTGGA GCCGGTGAGC GTGGGTCTCG CGGTATCATT GCAGCACTGG GGCCAGATGG TAAGCCCTCC CGTATCGTAG TTATCTACAC GACGGGGAGT CAGGCAACTA TGGATGAACG AAATAGACAG ATCGCTGAGA TAGGTGCCTC ACTGATTAAG CATTGGTAAC TGTCAGACCA AGTTTACTCA TATATACTTT AGATTGATTT AAAACTTCAT TTTTAATTTA AAAGGATCTA GGTGAAGATC CTTTTTGATA ATCTCATGAC CAAAATCCCT TAACGTGAGT TTTCGTTCCA CTGAGCGTCA GACCCCGTAG AAAAGATCAA AGGATCTTCT TGAGATCCTT TTTTTCTGCG CGTAATCTGC TGCTTGCAAA CAAAAAAACC ACCGCTACCA GCGGTGGTTT GTTTGCCGGA TCAAGAGCTA CCAACTCTTT TTCCGAAGGT AACTGGCTTC AGCAGAGCGC AGATACCAAA TACTGTCCTT CTAGTGTAGC CGTAGTTAGG CCACCACTTC AAGAACTCTG TAGCACCGCC TACATACCTC GCTCTGCTAA TCCTGTTACC AGTGGCTGCT GCCAGTGGCG ATAAGTCGTG TCTTACCGGG TTGGACTCAA GACGATAGTT ACCGGATAAG GCGCAGCGGT CGGGCTGAAC GGGGGGTTCG TGCACACAGC CCAGCTTGGA GCGAACGACC TACACCGAAC TGAGATACCT ACAGCGTGAG CTATGAGAAA GCGCCACGCT TCCCGAAGGG AGAAAGGCGG ACAGGTATCC GGTAAGCGGC AGGGTCGGAA CAGGAGAGCG CACGAGGGAG CTTCCAGGGG GAAACGCCTG GTATCTTTAT AGTCCTGTCG GGTTTCGCCA CCTCTGACTT GAGCGTCGAT TTTTGTGATG CTCGTCAGGG GGGCGGAGCC TATGGAAAAA CGCCAGCAAC GCGGCCTTTT TACGGTTCCT GGCCTTTTGC TGGCCTTTTG CTCACATGTT CTTTCCTGCG TTATCCCCTG ATTCTGTGGA TAACCGTATT ACCGCCTTTG AGTGAGCTGA TACCGCTCGC CGCAGCCGAA CGACCGAGCG CAGCGAGTCA GTGAGCGAGG AAGCGGAAGA GCGCCTGATG CGGTATTTTC TCCTTACGCA TCTGTGCGGT ATTTCACACC GCATATATGG TGCACTCTCA GTACAATCTG CTCTGATGCC GCATAGTTAA GCCAGTATAC ACTCCGCTAT CGCTACGTGA CTGGGTCATG GCTGCGCCCC GACACCCGCC AACACCCGCT GACGCGCCCT GACGGGCTTG TCTGCTCCCG GCATCCGCTT ACAGACAAGC TGTGACCGTC TCCGGGAGCT GCATGTGTCA GAGGTTTTCA CCGTCATCAC CGAAACGCGC GAGGCAGCTG CGGTAAAGCT CATCAGCGTG GTCGTGAAGC GATTCACAGA TGTCTGCCTG TTCATCCGCG TCCAGCTCGT TGAGTTTCTC CAGAAGCGTT AATGTCTGGC TTCTGATAAA GCGGGCCATG TTAAGGGCGG TTTTTTCCTG TTTGGTCACT GATGCCTCCG TGTAAGGGGG ATTTCTGTTC ATGGGGGTAA TGATACCGAT GAAACGAGAG AGGATGCTCA CGATACGGGT TACTGATGAT GAACATGCCC GGTTACTGGA ACGTTGTGAG GGTAAACAAC TGGCGGTATG GATGCGGCGG GACCAGAGAA AAATCACTCA GGGTCAATGC CAGCGCTTCG TTAATACAGA TGTAGGTGTT CCACAGGGTA GCCAGCAGCA TCCTGCGATG CAGATCCGGA ACATAATGGT GCAGGGCGCT GACTTCCGCG TTTCCAGACT TTACGAAACA CGGAAACCGA AGACCATTCA TGTTGTTGCT CAGGTCGCAG ACGTTTTGCA GCAGCAGTCG CTTCACGTTC GCTCGCGTAT CGGTGATTCA TTCTGCTAAC CAGTAAGGCA ACCCCGCCAG CCTAGCCGGG TCCTCAACGA CAGGAGCACG ATCATGCGCA CCCGTGGCCA GGACCCAACG CTGCCCGAGA TGCGCCGCGT GCGGCTGCTG GAGATGGCGG ACGCGATGGA TATGTTCTGC CAAGGGTTGG TTTGCGCATT CACAGTTCTC CGCAAGAATT GATTGGCTCC AATTCTTGGA GTGGTGAATC CGTTAGCGAG GTGCCGCCGG CTTCCATTCA GGTCGAGGTG GCCCGGCTCC ATGCACCGCG ACGCAACGCG GGGAGGCAGA CAAGGTATAG GGCGGCGCCT ACAATCCATG CCAACCCGTT CCATGTGCTC GCCGAGGCGG CATAAATCGC CGTGACGATC AGCGGTCCAG TGATCGAAGT TAGGCTGGTA AGAGCCGCGA GCGATCCTTG AAGCTGTCCC TGATGGTCGT CATCTACCTG CCTGGACAGC ATGGCCTGCA ACGCGGGCAT CCCGATGCCG CCGGAAGCGA GAAGAATCAT AATGGGGAAG GCCATCCAGC CTCGCGTCGT GAACGCCAGC AAGACGTAGC CCAGCGCGTC GGCCGTAACA ACACCATTTA AATGGAGTGG TTACAAATGG AGTGGTTAAT TAACAACACC ATTTGTCGAC GCTCTCCCTT ATGCGACTCC TGCATTAGGA AGCAGCCCAG TAGTAGGTTG AGGCCGTTGA GCACCGCCGC CGCAAGGAAT GGTGCATGCA AGGAGATGGC GCCCAACAGT CCCCCGGCCA CGGGGCCTGC CACCATACCC ACGCCGAAAC AAGCGCTCAT GAGCCCGAAG TGGCGAGCCC GATCTTCCCC ATCGGTGATG TCGGCGATAT AGGCGCCAGC AACCGCACCT GTGGCGCCGG TGATGCCGGC CACGATGCGT CCGGCGTAGA GGATCGAGAT CTCGATCCCG CGAAATTAAT ACGACTCACT ATAGGGAGAC CACAACGGTT TCCCTCTAGA AATAATTTTG TTTAACTTTA AGAAGGAGAT ATACCATGGC TCATCACCAT CACCATCATA TGGGTACCCT GGAAGCTCAG ACCCAGGGTC CTGGTTCGAT GGCGCTGACG GCCGAAGAGG AAACCATCGT CAAGACGGTG CACGATTTCG TCGAGAAGCA GGTCAAACCG GTGGTACGGG AGTTGGAGCA CGCCAACACC TATCCCGAAG AGCTGATCGA GACGATGAAG GAGATCGGTA TCTTCGGGCT CGCGATCCCG GAGCCGTACG GGTTCGGGGC GGTGTCCATG CCGTGTTACG TGCAGGTCGC CGAGGAACTG GCCAGGGGCT GGATGAGCCT GGCCGGCGCG ATGGGCGGCC ACACCGTGGT GTCGAAGCTG CTGTTGCTGT TCGGCACCGA GGAGCAGAAG CAGAAATACC TGCCGCGGAT GGCCACCGGT GAACTGCGCG CCACGATGGC GCTCACCGAA CCCGGTGGCG GGTCGGATCT GCAGGCCATG CGCACCGTCG CGCGCCGGGA CGGCGACGAC TACGTGATCA ACGGCAGCAA GACCTGGATC TCCAACGCGC GGCGCTCGGA TCTGGTGGCG CTGATGTGCA AGACCGATCC CGACGCGCAG CCCGCACACA AGGGTGTGTC GATCCTCCTG GTGGAGAAGG TGCCCGGCTT CGACGTGTCA CGCGACCTAC CCAAGCTGGG CTACAAGGGC GTGGAGAGCT GCGAGCTCAA CTTCACCGAC GCCCGGGTTC CGGTCTCCTC GCTGCTCGGC GACGACGAGG GCCGTGGGTT CGCGCAGATG ATGAAAGGCC TGGAGGTGGG CCGGTTGCAG GTCGCGGCGC GGGCAACGGG CGTGGCGCGT GCGGCGTTCG AGGATGCGCT GCGGTACTCC CAGGAGCGGG AGAGCTTCGG CAAGCCGATC TGGCAACACC AGTCGGTCGG AAACATGTTG GCCGACATGG GAACCAAGCT GTACGCAGCG CGCTCGCTGC TGCTCAGTGC GGCCGAGAAG TTCGACGCGG GGCAACGCTG TGACATGGAG GCCGGCATGG CCAAGCTGTT CGCGTCGGAG ACCGCGATGC AGATCGCACT GGACGCCGTA CGCGTGCACG GGGGCTACGG CTATTCCACC GAGTACGACG TCGAACGTTA CTTCCGCGAT GCGCCACTGA TGATCGTCGG CGAGGGCACC AACGAGATCC AGCGCAACGT GATCGCCAAA CAACTCGTCG CGCGCGGCGG TCTCGACATC AAACAGCACG AACAAGTTCT GCAGCCAAGC TTCTCGAGGA TCCGGCTGCT AACAAAGCCC GAAAGGAAGC TGAGTTGGCT GCTGCCACCG CTGAGCAATA ACTAGCATAA CCCCTTGGGG CCTCTAAACG GGTCTTGAGG GGTTTTTTGC TGAAAGGAGG AACTATATCC GGATATCCAC AGGACGGGTG TGGTCGCCAT GATCGCGTAG TCGATAGTGG CTCCAAGTAG CGAAGCGAGC AGGACTGGGC GGCGGCCAAA GCGGTCGGAC AGTGCTCCGA GAACGGGTGC GCATAGAAAT TGCATCAACG CATATAGCGC TAGCAGCACG CCATAGTGAC TGGCGATGCT GTCGGAATGG ACGATATCCC GCAAGAGGCC CGGCAGTACC GGCATAACCA AGCCTATGCC TACAGCATCC AGGGTGACGG TGCCGAGGAT GACGATGAGC GCATTGTTAG ATTTCATACA CGGTGCCTGA CTGCGTTAGC AATTTAACTG TGATAAACTA CCGCATTAAA GCTTATCGAT GATAAGCTGT CAAACATGAG AA