MyavA.01188.b
Alpha-ketoglutarate-dependent taurine dioxygenase
| CENTER ID: | MyavA.01188.b |
| ORGANISM: | Mycobacterium avium 104 |
| ASSOCIATED DISEASE: | Johne's disease, paratuberculosis |
| CURRENT STATUS: | in PDB |
| COMMUNITY REQUEST: | False |
| NIH RISK GROUP: | 2 |
| SELECT AGENT: | False |
| NIH PRIORITY pathogens category: |
IIIC |
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Proteins
| CENTER REFERENCE ID |
DOMAIN/REGION DESCRIPTION |
INFO | AA START |
AA STOP |
ORDER MATERIAL |
|---|---|---|---|---|---|
| MyavA.01188.b.A1.PW28977 | Full length( MyavA.01188.b ) | 1 | 297 |
Structures
3R1J
DEPOSITED: 3/10/2011
DETERMINATION: XRay
CLONE: MyavA.01188.b.A1.GE29072
PROTEIN: MyavA.01188.b.A1.PW28977
Publications by SSGCID
Increasing the structural coverage of tuberculosis drug targets.
Abendroth J, Abramov A, Armour B, Barrett LK, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Ferrell M, Fox D, Gardberg AS, Hewitt SN, Lorimer D, Lyons-Abbott S, Mundt E, Muruthi MM, Myers J, Myler PJ, Napuli AJ, Phan I, Sekar A, Serbzhinskiy D, Stacy R, Staker BL, Stewart LJ, Taylor BM, Thompkins K, Tran N, Van Voorhis WC, Zhang Y
Tuberculosis (Edinb) - 2014
volume 95, issue 2, pages 142-8
PMID: 25613812; PMCID: PMC4361283
PDB:
3GVC,
3GVG,
3GWC,
3H7F,
3H81,
3HE2,
3HWI,
3HWK,
3HZG,
3ICO,
3KHP,
3LLS,
3MOY,
3MPZ,
3MYB,
3NDN,
3NDO,
3NF4,
3NG3,
3NJD,
3NWO,
3O0M,
3O38,
3OC6,
3OC7,
3OEC,
3OI9,
3OKS,
3OL3,
3OL4,
3OME,
3P0T,
3P2Y,
3P4I,
3P4T,
3P5M,
3P85,
3PE8,
3PGX,
3PK0,
3PPI,
3PXX,
3PZY,
3Q1T,
3Q8N,
3QBP,
3QDF,
3QH4,
3QHA,
3QIV,
3QK8,
3QKA,
3QLJ,
3QMJ,
3QRE,
3QUA,
3QUV,
3QXI,
3QXZ,
3QYR,
3R0O,
3R1I,
3R1J,
3R20,
3R2N,
3R4T,
3R6H,
3R6O,
3R7K,
3R8C,
3R9P,
3R9Q,
3R9R,
3R9S,
3R9T,
3RD5,
3RD7,
3RD8,
3RFQ,
3RIH,
3RR2,
3RR6,
3RRP,
3RRV,
3RSI,
3RV2,
3S55,
3S82,
3SBX,
3SF6,
3SLL,
3SVK,
3SVT,
3SWO,
3SWT,
3SWX,
3SX2,
3T3W,
3T7C,
3TAV,
3TCR,
3TDE,
3TJR,
3TL3,
3TLF,
3TRR,
3TSC,
3TX2,
3TZQ,
3TZU,
3U0A,
3U0B,
3UCX,
3UVE,
4DI1,
4DIE,
4DQ8,
4DXL,
4ED4,
4EGE,
4EGF,
4EMD,
4EO9,
4EYE,
4F3W,
4F47,
4FFC,
4GK6,
4HDT,
4HR3,
4I1Y,
4IJN,
4IV6,
4IZ9,
4J5I,
4KAM,
4LGV,
4O2D,
5EJ2
External Resources
| RESOURCE | REFERENCE ID |
|---|---|
| BV-BRC: | fig|243243.7.peg.4277 |
| RefSeq: | YP_883488.1 |
| UniProt: | A0A0H2ZSG9 |
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols.
To find the specific sequence of any material you may have ordered, click on the "info" button next to the name of that material.
AA Sequence
MTGQITVTKL GSRIGARVDG VRLGGDLDDA TVEQIRRALL THKVIFFRHQ HHLDDSRQLE FARLLGTPIG HPAASALAAK HLPVITPIDS EYGKATRWHT DVTFAANYPA ASILRAVTLP SYGGSTLWAS TVAAYQQLPE PLRHLTENLW ALHTNRYDYV RNDPMNDTQR AFRQAFEKPD FRTEHPVVRV HPETGERALL AGDFVRGFVG LDGHESSVLL ELLQRRITMP ENTVRWSWAP GDVAMWDNRA TQHRAIDDYD DQPRLMHRIT LMGDVPVNVH GERSRVISGA PLEVLAS
NT Sequence
ATGACAGGTC AGATAACCGT CACCAAGCTG GGCAGCCGGA TCGGCGCCCG GGTGGACGGG GTGCGCCTCG GCGGCGACCT CGACGACGCC ACGGTCGAGC AGATCCGCCG CGCGCTGTTG ACCCACAAGG TGATCTTCTT CCGTCACCAG CACCACCTCG ACGACTCCCG GCAGCTCGAG TTCGCCAGGC TGCTGGGCAC CCCCATCGGG CACCCGGCCG CCTCGGCGCT GGCCGCCAAG CACCTTCCGG TGATCACGCC CATCGACTCC GAGTATGGCA AGGCCACCCG CTGGCATACC GACGTGACGT TCGCCGCCAA CTATCCGGCG GCCTCGATCC TGCGGGCGGT CACCCTGCCC AGCTACGGCG GCTCGACGCT GTGGGCCTCC ACGGTCGCGG CCTACCAGCA GCTGCCCGAG CCGCTGCGGC ACCTGACCGA AAACCTGTGG GCGCTGCACA CCAACCGCTA TGACTACGTG CGCAACGACC CCATGAACGA CACCCAGCGG GCGTTTCGCC AGGCGTTCGA GAAGCCGGAC TTTCGCACCG AGCACCCCGT GGTGCGGGTG CACCCGGAGA CCGGGGAGCG CGCCCTGCTG GCCGGGGATT TCGTGCGCGG TTTCGTCGGC CTGGACGGCC ACGAGTCCAG CGTGCTGCTG GAGCTACTGC AGCGGCGAAT CACCATGCCG GAGAACACCG TTCGCTGGAG TTGGGCGCCG GGGGACGTCG CCATGTGGGA CAACCGCGCC ACCCAGCACC GGGCGATCGA CGACTACGAC GACCAGCCCC GGCTGATGCA CCGCATCACA TTGATGGGCG ACGTGCCGGT CAACGTGCAC GGCGAGCGCA GCCGGGTGAT CAGCGGCGCC CCGCTCGAGG TGCTGGCCAG C
Details for MyavA.01188.b.A1.PW28977
| PURIFICATION DATe: | 10/11/2010 |
| CONCENTRATION: | 28.9mg/ml |
| OBSERVED MW: | data unavailable |
| EXPRESSION LEVEL: | High Expression |
| PROTEIN PURIFICATION BUFFER: | 25 mM HEPES pH 7.0, 500 mM NaCl, 5% Glycerol , 2 mM DTT, and 0.025% Azide |
| EXPRESSION HOST: | data unavailable |
| VIAL COUNT (approx.): | 6 |
| VIAL VOLUME: | 100µl |
| PERCENT IDENTITY: | 33 |
| PERCENT COVERAGE: | 49 |
Protocol Notes
notes unavailable
Validated AA Sequence
MTGQITXTKL GSXXRRPGGR GAXRRRPRRR HGRADPPRAV DPQGDLLPSP APPRRLPAAR VRQAAGHPHR APGRLGAGRQ APSGDHAHRL RVWQGHPLAY RRDVRRQLSG GLDPAGGHPA QLRRLDAVGL HGRGLPAAAR AAAAPDRKPV GAAHQPL
Validated NT Sequence
ttcgggcttt gttagcagcc ggntcctcga gaagcttggc tgcagaactt gttcgtgctg tttattagct ggccagcacc tcgagcgggg cgccgctgat cacccggctg cgctcgccgt gcacgttgac cggcacgtcg cccatcaacg tgatgcggtg catcagccgg ggctggtcgt cgtagtcgtc gatcgcccgg tgctgggtgg cgcggttgtc ccacatggcg acgtcccccg gcgcccaact ccagcgaacg gtgttctccg gcatggtgat tcgccgctgc agtagctcca gcagcacgct ggactcgtgg ccgtccaggc cgacgaaacc gcgcacgaaa tccccggcca gcagggcgcg ctccccggtc tccgggtgca cccgcaccac ggggtgctcg gtgcgaaagt ccggcttctc gaacgcctgg cgaaacgccc gctgggtgtc gttcatgggg tcggtgcgca cgtagtcata gcggttggtg tgcagcgccc acaggttttc ggtcaggtgc cgcagcggct cgggcagctg ctggtaggcc gcgaccgtgg aggcccacag cgtcgagccg ccgtagctgg gcagggtgac cgcccgcagg atcgaggccg ccggatagtt ggcggcgaac gtcacgtcgg tatgccagcg ggtggccttg ccatactcgg agtcgatggg cgtgatcacc ggaaggtgct tggcggccag cgccgaggcg gccgggtgcc cgatgggggt gcccagcagc ctggcgaact cgagctgccg ggagtcgtcg aggtggtgct ggtgacggaa gaagatcacc ttgtgggtca acagcgcgcg gcggatctgc tcgaccgtgg cgtcgtcgag gtcgccgccg angcgcaccc cgtccacccg ggcgccgatn cnggctgccc agcttggtga nggttatctg acctgtcatc gaaccnggac cctgggtctg ancttccnng nacccatatg atggngatgg ngatgagcca tggnntatcn nnntaannnn nnaannnatt tcnnganggn aancgtnngt nnnnnnnann na
Expressed Protein Sequence
MAHHHHHHMG TLEAQTQGPG SMTGQITVTK LGSRIGARVD GVRLGGDLDD ATVEQIRRAL LTHKVIFFRH QHHLDDSRQL EFARLLGTPI GHPAASALAA KHLPVITPID SEYGKATRWH TDVTFAANYP AASILRAVTL PSYGGSTLWA STVAAYQQLP EPLRHLTENL WALHTNRYDY VRNDPMNDTQ RAFRQAFEKP DFRTEHPVVR VHPETGERAL LAGDFVRGFV GLDGHESSVL LELLQRRITM PENTVRWSWA PGDVAMWDNR ATQHRAIDDY DDQPRLMHRI TLMGDVPVNV HGERSRVISG APLEVLAS
Full NT Sequence (Expression Vector + Insert)
TTCTTGAAGA CGAAAGGGCC TCGTGATACG CCTATTTTTA TAGGTTAATG TCATGATAAT AATGGTTTCT TAGACGTCAG GTGGCACTTT TCGGGGAAAT GTGCGCGGAA CCCCTATTTG TTTATTTTTC TAAATACATT CAAATATGTA TCCGCTCATG AGACAATAAC CCTGATAAAT GCTTCAATAA TATTGAAAAA GGAAGAGTAT GAGTATTCAA CATTTCCGTG TCGCCCTTAT TCCCTTTTTT GCGGCATTTT GCCTTCCTGT TTTTGCTCAC CCAGAAACGC TGGTGAAAGT AAAAGATGCT GAAGATCAGT TGGGTGCACG AGTGGGTTAC ATCGAACTGG ATCTCAACAG CGGTAAGATC CTTGAGAGTT TTCGCCCCGA AGAACGTTTT CCAATGATGA GCACTTTTAA AGTTCTGCTA TGTGGCGCGG TATTATCCCG TGTTGACGCC GGGCAAGAGC AACTCGGTCG CCGCATACAC TATTCTCAGA ATGACTTGGT TGAGTACTCA CCAGTCACAG AAAAGCATCT TACGGATGGC ATGACAGTAA GAGAATTATG CAGTGCTGCC ATAACCATGA GTGATAACAC TGCGGCCAAC TTACTTCTGA CAACGATCGG AGGACCGAAG GAGCTAACCG CTTTTTTGCA CAACATGGGG GATCATGTAA CTCGCCTTGA TCGTTGGGAA CCGGAGCTGA ATGAAGCCAT ACCAAACGAC GAGCGTGACA CCACGATGCC TGCAGCAATG GCAACAACGT TGCGCAAACT ATTAACTGGC GAACTACTTA CTCTAGCTTC CCGGCAACAA TTAATAGACT GGATGGAGGC GGATAAAGTT GCAGGACCAC TTCTGCGCTC GGCCCTTCCG GCTGGCTGGT TTATTGCTGA TAAATCTGGA GCCGGTGAGC GTGGGTCTCG CGGTATCATT GCAGCACTGG GGCCAGATGG TAAGCCCTCC CGTATCGTAG TTATCTACAC GACGGGGAGT CAGGCAACTA TGGATGAACG AAATAGACAG ATCGCTGAGA TAGGTGCCTC ACTGATTAAG CATTGGTAAC TGTCAGACCA AGTTTACTCA TATATACTTT AGATTGATTT AAAACTTCAT TTTTAATTTA AAAGGATCTA GGTGAAGATC CTTTTTGATA ATCTCATGAC CAAAATCCCT TAACGTGAGT TTTCGTTCCA CTGAGCGTCA GACCCCGTAG AAAAGATCAA AGGATCTTCT TGAGATCCTT TTTTTCTGCG CGTAATCTGC TGCTTGCAAA CAAAAAAACC ACCGCTACCA GCGGTGGTTT GTTTGCCGGA TCAAGAGCTA CCAACTCTTT TTCCGAAGGT AACTGGCTTC AGCAGAGCGC AGATACCAAA TACTGTCCTT CTAGTGTAGC CGTAGTTAGG CCACCACTTC AAGAACTCTG TAGCACCGCC TACATACCTC GCTCTGCTAA TCCTGTTACC AGTGGCTGCT GCCAGTGGCG ATAAGTCGTG TCTTACCGGG TTGGACTCAA GACGATAGTT ACCGGATAAG GCGCAGCGGT CGGGCTGAAC GGGGGGTTCG TGCACACAGC CCAGCTTGGA GCGAACGACC TACACCGAAC TGAGATACCT ACAGCGTGAG CTATGAGAAA GCGCCACGCT TCCCGAAGGG AGAAAGGCGG ACAGGTATCC GGTAAGCGGC AGGGTCGGAA CAGGAGAGCG CACGAGGGAG CTTCCAGGGG GAAACGCCTG GTATCTTTAT AGTCCTGTCG GGTTTCGCCA CCTCTGACTT GAGCGTCGAT TTTTGTGATG CTCGTCAGGG GGGCGGAGCC TATGGAAAAA CGCCAGCAAC GCGGCCTTTT TACGGTTCCT GGCCTTTTGC TGGCCTTTTG CTCACATGTT CTTTCCTGCG TTATCCCCTG ATTCTGTGGA TAACCGTATT ACCGCCTTTG AGTGAGCTGA TACCGCTCGC CGCAGCCGAA CGACCGAGCG CAGCGAGTCA GTGAGCGAGG AAGCGGAAGA GCGCCTGATG CGGTATTTTC TCCTTACGCA TCTGTGCGGT ATTTCACACC GCATATATGG TGCACTCTCA GTACAATCTG CTCTGATGCC GCATAGTTAA GCCAGTATAC ACTCCGCTAT CGCTACGTGA CTGGGTCATG GCTGCGCCCC GACACCCGCC AACACCCGCT GACGCGCCCT GACGGGCTTG TCTGCTCCCG GCATCCGCTT ACAGACAAGC TGTGACCGTC TCCGGGAGCT GCATGTGTCA GAGGTTTTCA CCGTCATCAC CGAAACGCGC GAGGCAGCTG CGGTAAAGCT CATCAGCGTG GTCGTGAAGC GATTCACAGA TGTCTGCCTG TTCATCCGCG TCCAGCTCGT TGAGTTTCTC CAGAAGCGTT AATGTCTGGC TTCTGATAAA GCGGGCCATG TTAAGGGCGG TTTTTTCCTG TTTGGTCACT GATGCCTCCG TGTAAGGGGG ATTTCTGTTC ATGGGGGTAA TGATACCGAT GAAACGAGAG AGGATGCTCA CGATACGGGT TACTGATGAT GAACATGCCC GGTTACTGGA ACGTTGTGAG GGTAAACAAC TGGCGGTATG GATGCGGCGG GACCAGAGAA AAATCACTCA GGGTCAATGC CAGCGCTTCG TTAATACAGA TGTAGGTGTT CCACAGGGTA GCCAGCAGCA TCCTGCGATG CAGATCCGGA ACATAATGGT GCAGGGCGCT GACTTCCGCG TTTCCAGACT TTACGAAACA CGGAAACCGA AGACCATTCA TGTTGTTGCT CAGGTCGCAG ACGTTTTGCA GCAGCAGTCG CTTCACGTTC GCTCGCGTAT CGGTGATTCA TTCTGCTAAC CAGTAAGGCA ACCCCGCCAG CCTAGCCGGG TCCTCAACGA CAGGAGCACG ATCATGCGCA CCCGTGGCCA GGACCCAACG CTGCCCGAGA TGCGCCGCGT GCGGCTGCTG GAGATGGCGG ACGCGATGGA TATGTTCTGC CAAGGGTTGG TTTGCGCATT CACAGTTCTC CGCAAGAATT GATTGGCTCC AATTCTTGGA GTGGTGAATC CGTTAGCGAG GTGCCGCCGG CTTCCATTCA GGTCGAGGTG GCCCGGCTCC ATGCACCGCG ACGCAACGCG GGGAGGCAGA CAAGGTATAG GGCGGCGCCT ACAATCCATG CCAACCCGTT CCATGTGCTC GCCGAGGCGG CATAAATCGC CGTGACGATC AGCGGTCCAG TGATCGAAGT TAGGCTGGTA AGAGCCGCGA GCGATCCTTG AAGCTGTCCC TGATGGTCGT CATCTACCTG CCTGGACAGC ATGGCCTGCA ACGCGGGCAT CCCGATGCCG CCGGAAGCGA GAAGAATCAT AATGGGGAAG GCCATCCAGC CTCGCGTCGT GAACGCCAGC AAGACGTAGC CCAGCGCGTC GGCCGTAACA ACACCATTTA AATGGAGTGG TTACAAATGG AGTGGTTAAT TAACAACACC ATTTGTCGAC GCTCTCCCTT ATGCGACTCC TGCATTAGGA AGCAGCCCAG TAGTAGGTTG AGGCCGTTGA GCACCGCCGC CGCAAGGAAT GGTGCATGCA AGGAGATGGC GCCCAACAGT CCCCCGGCCA CGGGGCCTGC CACCATACCC ACGCCGAAAC AAGCGCTCAT GAGCCCGAAG TGGCGAGCCC GATCTTCCCC ATCGGTGATG TCGGCGATAT AGGCGCCAGC AACCGCACCT GTGGCGCCGG TGATGCCGGC CACGATGCGT CCGGCGTAGA GGATCGAGAT CTCGATCCCG CGAAATTAAT ACGACTCACT ATAGGGAGAC CACAACGGTT TCCCTCTAGA AATAATTTTG TTTAACTTTA AGAAGGAGAT ATACCATGGC TCATCACCAT CACCATCATA TGGGTACCCT GGAAGCTCAG ACCCAGGGTC CTGGTTCGAT GACAGGTCAG ATAACCGTCA CCAAGCTGGG CAGCCGGATC GGCGCCCGGG TGGACGGGGT GCGCCTCGGC GGCGACCTCG ACGACGCCAC GGTCGAGCAG ATCCGCCGCG CGCTGTTGAC CCACAAGGTG ATCTTCTTCC GTCACCAGCA CCACCTCGAC GACTCCCGGC AGCTCGAGTT CGCCAGGCTG CTGGGCACCC CCATCGGGCA CCCGGCCGCC TCGGCGCTGG CCGCCAAGCA CCTTCCGGTG ATCACGCCCA TCGACTCCGA GTATGGCAAG GCCACCCGCT GGCATACCGA CGTGACGTTC GCCGCCAACT ATCCGGCGGC CTCGATCCTG CGGGCGGTCA CCCTGCCCAG CTACGGCGGC TCGACGCTGT GGGCCTCCAC GGTCGCGGCC TACCAGCAGC TGCCCGAGCC GCTGCGGCAC CTGACCGAAA ACCTGTGGGC GCTGCACACC AACCGCTATG ACTACGTGCG CAACGACCCC ATGAACGACA CCCAGCGGGC GTTTCGCCAG GCGTTCGAGA AGCCGGACTT TCGCACCGAG CACCCCGTGG TGCGGGTGCA CCCGGAGACC GGGGAGCGCG CCCTGCTGGC CGGGGATTTC GTGCGCGGTT TCGTCGGCCT GGACGGCCAC GAGTCCAGCG TGCTGCTGGA GCTACTGCAG CGGCGAATCA CCATGCCGGA GAACACCGTT CGCTGGAGTT GGGCGCCGGG GGACGTCGCC ATGTGGGACA ACCGCGCCAC CCAGCACCGG GCGATCGACG ACTACGACGA CCAGCCCCGG CTGATGCACC GCATCACATT GATGGGCGAC GTGCCGGTCA ACGTGCACGG CGAGCGCAGC CGGGTGATCA GCGGCGCCCC GCTCGAGGTG CTGGCCAGCA AACAGCACGA ACAAGTTCTG CAGCCAAGCT TCTCGAGGAT CCGGCTGCTA ACAAAGCCCG AAAGGAAGCT GAGTTGGCTG CTGCCACCGC TGAGCAATAA CTAGCATAAC CCCTTGGGGC CTCTAAACGG GTCTTGAGGG GTTTTTTGCT GAAAGGAGGA ACTATATCCG GATATCCACA GGACGGGTGT GGTCGCCATG ATCGCGTAGT CGATAGTGGC TCCAAGTAGC GAAGCGAGCA GGACTGGGCG GCGGCCAAAG CGGTCGGACA GTGCTCCGAG AACGGGTGCG CATAGAAATT GCATCAACGC ATATAGCGCT AGCAGCACGC CATAGTGACT GGCGATGCTG TCGGAATGGA CGATATCCCG CAAGAGGCCC GGCAGTACCG GCATAACCAA GCCTATGCCT ACAGCATCCA GGGTGACGGT GCCGAGGATG ACGATGAGCG CATTGTTAGA TTTCATACAC GGTGCCTGAC TGCGTTAGCA ATTTAACTGT GATAAACTAC CGCATTAAAG CTTATCGATG ATAAGCTGTC AAACATGAGA A