HosaA.19747.a

Cadherin-1; E-cadherin

CENTER ID: HosaA.19747.a
ORGANISM: Homo sapiens
ASSOCIATED DISEASE:
CURRENT STATUS: in PDB
COMMUNITY REQUEST: True
NIH RISK GROUP: unclassified
SELECT AGENT: False
NIH PRIORITY
pathogens category:		 unclassified

Ordering Clones & Proteins

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Structures
6CXY
DEPOSITED: 4/4/2018
DETERMINATION: XRay
CLONE: HosaA.19747.a.KW2.GE41924
PROTEIN: HosaA.19747.a.KW2.PC00156
6VEL
DEPOSITED: 1/2/2020
DETERMINATION: XRay
CLONE: HosaA.19747.a.KW2.GE41924
PROTEIN: HosaA.19747.a.KW2.PC00161
7STZ
DEPOSITED: 11/15/2021
DETERMINATION: XRay
CLONE: HosaA.19747.a.LS31.GE43558
PROTEIN: HosaA.19747.a.LS31.PC00180
Publications by SSGCID
Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography
Myler P, Staker B, Hammerson B, Bolejack M, Maker A, Schecterson L, Gumbiner B
PNAS Nexus - 2022
PMID: 36157596; PMCID: PMC9491697
PDB: 6VEL, 7STZ
Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody
Dranow DM, Edwards TE, Myler PJ, Staker B, Maker A, Gumbiner B, Xie B, Priest AV, Phan JN, Sivasankar S
Proc. Natl. Acad. Sci. U.S.A. - 2022
volume 119, issue 32, pages e2204473119
PMID: 35921442; PMCID: PMC9371698
PDB: 6CXY
External Resources
RESOURCE REFERENCE ID
UniProt: P12830
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "info" button next to the name of that material.
AA Sequence
MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG GQFVVTTNPV NNDGILKTAK GLDFEAKQQY ILHVAVTNVV PFEVSLTTST ATVTVDVLDV NEAPIFVPPE KRVEVSEDFG VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG AISTRAELDR EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI ILKPKMALEV GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP VEAGLQIPAI LGILGGILAL LILILLLLLF LRRRAVVKEP LLPPEDDTRD NVYYYDEEGG GEEDQDFDLS QLHRGLDARP EVTRNDVAPT LMSVPRYLPR PANPDEIGNF IDENLKAADT DPTAPPYDSL LVFDYEGSGS EAASLSSLNS SESDKDQDYD YLNEWGNRFK KLADMYGGGE DD
NT Sequence
atgggccctt ggagccgcag cctctcggcg ctgctgctgc tgctgcaggt ctcctcttgg ctctgccagg agccggagcc ctgccaccct ggctttgacg ccgagagcta cacgttcacg gtgccccggc gccacctgga gagaggccgc gtcctgggca gagtgaattt tgaagattgc accggtcgac aaaggacagc ctatttttcc ctcgacaccc gattcaaagt gggcacagat ggtgtgatta cagtcaaaag gcctctacgg tttcataacc cacagatcca tttcttggtc tacgcctggg actccaccta cagaaagttt tccaccaaag tcacgctgaa tacagtgggg caccaccacc gccccccgcc ccatcaggcc tccgtttctg gaatccaagc agaattgctc acatttccca actcctctcc tggcctcaga agacagaaga gagactgggt tattcctccc atcagctgcc cagaaaatga aaaaggccca tttcctaaaa acctggttca gatcaaatcc aacaaagaca aagaaggcaa ggttttctac agcatcactg gccaaggagc tgacacaccc cctgttggtg tctttattat tgaaagagaa acaggatggc tgaaggtgac agagcctctg gatagagaac gcattgccac atacactctc ttctctcacg ctgtgtcatc caacgggaat gcagttgagg atccaatgga gattttgatc acggtaaccg atcagaatga caacaagccc gaattcaccc aggaggtctt taaggggtct gtcatggaag gtgctcttcc aggaacctct gtgatggagg tcacagccac agacgcggac gatgatgtga acacctacaa tgccgccatc gcttacacca tcctcagcca agatcctgag ctccctgaca aaaatatgtt caccattaac aggaacacag gagtcatcag tgtggtcacc actgggctgg accgagagag tttccctacg tataccctgg tggttcaagc tgctgacctt caaggtgagg ggttaagcac aacagcaaca gctgtgatca cagtcactga caccaacgat aatcctccga tcttcaatcc caccacgtac aagggtcagg tgcctgagaa cgaggctaac gtcgtaatca ccacactgaa agtgactgat gctgatgccc ccaatacccc agcgtgggag gctgtataca ccatattgaa tgatgatggt ggacaatttg tcgtcaccac aaatccagtg aacaacgatg gcattttgaa aacagcaaag ggcttggatt ttgaggccaa gcagcagtac attctacacg tagcagtgac gaatgtggta ccttttgagg tctctctcac cacctccaca gccaccgtca ccgtggatgt gctggatgtg aatgaagccc ccatctttgt gcctcctgaa aagagagtgg aagtgtccga ggactttggc gtgggccagg aaatcacatc ctacactgcc caggagccag acacatttat ggaacagaaa ataacatatc ggatttggag agacactgcc aactggctgg agattaatcc ggacactggt gccatttcca ctcgggctga gctggacagg gaggattttg agcacgtgaa gaacagcacg tacacagccc taatcatagc tacagacaat ggttctccag ttgctactgg aacagggaca cttctgctga tcctgtctga tgtgaatgac aacgccccca taccagaacc tcgaactata ttcttctgtg agaggaatcc aaagcctcag gtcataaaca tcattgatgc agaccttcct cccaatacat ctcccttcac agcagaacta acacacgggg cgagtgccaa ctggaccatt cagtacaacg acccaaccca agaatctatc attttgaagc caaagatggc cttagaggtg ggtgactaca aaatcaatct caagctcatg gataaccaga ataaagacca agtgaccacc ttagaggtca gcgtgtgtga ctgtgaaggg gccgccggcg tctgtaggaa ggcacagcct gtcgaagcag gattgcaaat tcctgccatt ctggggattc ttggaggaat tcttgctttg ctaattctga ttctgctgct cttgctgttt cttcggagga gagcggtggt caaagagccc ttactgcccc cagaggatga cacccgggac aacgtttatt actatgatga agaaggaggc ggagaagagg accaggactt tgacttgagc cagctgcaca ggggcctgga cgctcggcct gaagtgactc gtaacgacgt tgcaccaacc ctcatgagtg tcccccggta tcttccccgc cctgccaatc ccgatgaaat tggaaatttt attgatgaaa atctgaaagc ggctgatact gaccccacag ccccgcctta tgattctctg ctcgtgtttg actatgaagg aagcggttcc gaagctgcta gtctgagctc cctgaactcc tcagagtcag acaaagacca ggactatgac tacttgaacg aatggggcaa tcgcttcaag aagctggctg acatgtacgg aggcggcgag gacgactag