CrpaA.00612.a

Lysine--tRNA ligase; lysyl-tRNA synthetase

CENTER ID: CrpaA.00612.a
ORGANISM: Cryptosporidium parvum Iowa II
ASSOCIATED DISEASE: cryptosporidiosis - (diarrheal disease)
CURRENT STATUS: in PDB
COMMUNITY REQUEST: True
NIH RISK GROUP: 2
SELECT AGENT: False
NIH PRIORITY
pathogens category:		 IIIB

Ordering Clones & Proteins

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Structures
5ELN
DEPOSITED: 11/4/2015
DETERMINATION: XRay
CLONE: CrpaA.00612.a.A3.GE39020
PROTEIN: CrpaA.00612.a.A3.PW37710
5ELO
DEPOSITED: 11/4/2015
DETERMINATION: XRay
CLONE: CrpaA.00612.a.A3.GE39020
PROTEIN: CrpaA.00612.a.A3.PW37710
6BNI
DEPOSITED: 11/16/2017
DETERMINATION: XRay
CLONE: CrpaA.00612.a.A3.GE39020
PROTEIN: CrpaA.00612.a.A3.PW37710
6C86
DEPOSITED: 1/24/2018
DETERMINATION: XRay
CLONE: CrpaA.00612.a.A3.GE39020
PROTEIN: CrpaA.00612.a.A3.PW37710
Publications by SSGCID
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
Choi R, Dranow DM, Edwards TE, Lorimer DD, Myler PJ, Nakazawa-Hewitt S, Sharma A, Van Voorhis WC, Ojo KK, Forte B, Hallyburton I, Jansen C, Baragana B, Hulverson MA, Gray DW, Read KD, Walpole C, Gilbert IH, Ferguson L, Bueren-Calabuig J, Pisco JP, Peet C, Norcross N, Robinson DA, Anderson M, Brooks CF, Cooper CA, Horst BG, Jimenez-Diaz B, Love M, Miller P, O'Neill S, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Tamaki FK, Tamar J, Torrie LS, Vantaux A, Vinayak S, Witkowski B, Wittlin S, Zuccotto F, Angulo-Barturen IA, Sinden R, Baum J, Gamo F-J, Maser P, Kyle D, Winzeler E, Willis P, Wyatt PG, Floyd D, Matthews D, Striepen B, Huston CD, Fairlamb AH, Pisliakov A, Damerow S, Dowers K, Jumani RS, Maher S, Matthews H, McNamarra C
Proc. Natl. Acad. Sci. U.S.A. - 2019
PMID: 30894487 ; PMCID: PMC6452685
PDB: 5ELN, 5ELO
External Resources
RESOURCE REFERENCE ID
EuPathDB: CryptoDB:cgd4_2370
RefSeq: XP_625825.1
UniProt: Q5CR27
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "info" button next to the name of that material.
AA Sequence
MPCLSYILAA LVETIIRLLF FFNYFVRMST EMNNQSQISD TLDSVHYTDN RYKMMECIKD AGRPFYPHKF KISMSLPAYA LKYGNVENGY IDKDTTLSLS GRVTSIRSSS SKLIFYDIFC EEQKVQIIAN IMEHDISTGE FSVSHSEIRR GDVVGFTGFP GKSKRGELSL FSKSVVLLSP CYHMLPTAIS GLKDQEVRYR QRYLDLMLNE ESRKVFKLRS RAIKYIRNYF DRLGFLEVET PMLNMIYGGA AARPFITYHN ELETQLYMRI APELYLKQLI VGGLDKVYEI GKNFRNEGID LTHNPEFTAM EFYMAYADYY DLMDLTEELI SGLVLEIHGS LKIPYHPDGP EGKCIEIDFT TPWKRFSFVE EIESGLGEKL KRPLDSQENI DFMVEMCEKH EIELPHPRTA AKLLDKLAGH FVETKCTNPS FIIDHPQTMS PLAKWHREKP EMTERFELFV LGKELCNAYT ELNEPLQQRK FFEQQADAKA SGDVEACPID ETFCLALEHG LPPTGGWGLG IDRLIMFLAD KNNIKEVILF PAMRNVKQNA QHSNQHSGN
NT Sequence
atgccttgtt taagctacat attggcggcc ctcgttgaga cgataatcag acttcttttt tttttcaatt attttgttag aatgagcact gaaatgaata atcaatctca aattagtgat acgctagaca gcgtacacta tactgataat aggtacaaaa tgatggagtg tataaaggac gcaggcagac cgttttatcc acacaagttt aaaatttcga tgtcgcttcc agcatatgct ttgaaatacg gtaatgttga aaatggatat attgacaaag acacaactct ttcgttgtct ggaagagtca catcaattcg aagttcaagc tctaaattaa tattttatga tattttttgc gaggaacaga aagtgcaaat tatcgcaaat attatggagc acgacattag cactggcgag ttctctgttt ctcactcaga aattagacga ggagatgttg ttggatttac aggatttcca ggaaaatcaa agagaggaga gttatcgtta tttagcaaga gtgtagtttt gctttctcca tgctatcata tgttgcctac ggcgatttct ggtctgaaag atcaagaagt aagatacagg caaagatatc ttgatttgat gttgaacgag gaaagtagaa aagttttcaa actaagaagc agagctatta aatatattag gaattatttt gatagactcg ggtttttaga agtagaaact cctatgttaa atatgattta tggaggggca gccgcaagac catttattac ttaccataat gagctcgaga ctcaactcta tatgagaatt gctccagagc tctatttaaa acagttaatt gttggcggtc tagacaaagt atatgaaata ggaaaaaact ttaggaatga aggaatagat ttaacacaca accctgagtt cacagcaatg gagttttaca tggcatatgc tgattattat gatttaatgg atctgactga ggagttaata agtggcctgg tgcttgaaat tcatgggagt ctaaagattc cttaccatcc agatggtcct gaaggcaagt gtattgaaat agacttcaca acgccttgga aaaggttctc atttgttgaa gaaattgagt ctggattagg agaaaagcta aaaagaccat tagactctca ggagaatatc gattttatgg tagaaatgtg cgagaagcat gagattgaac tcccccatcc tagaactgct gctaagcttc ttgataaatt ggctgggcac tttgttgaga ctaagtgcac taatccctcg tttatcattg atcatcctca aactatgtct ccattggcaa aatggcatag agaaaagcct gaaatgaccg aaagattcga gcttttcgtt ttaggaaaag aactttgtaa tgcatatact gaattaaacg aacctctaca acaaagaaaa ttttttgaac agcaggctga tgcaaaggca tctggcgatg tcgaggcttg cccaattgat gagacattct gtcttgcatt agagcacgga ttaccaccca cagggggatg gggccttggt atcgataggt taattatgtt cttggcagat aaaaacaata tcaaagaagt aattctgttc ccagctatga gaaacgttaa acaaaatgcc caacatagca accaacatag cggaaattag