CoimA.00174.a
Serine/threonine-protein phosphatase (EC 3.1.3.16); calcineurin A ortholog
| CENTER ID: | CoimA.00174.a |
| ORGANISM: | Coccidioides immitis RS |
| ASSOCIATED DISEASE: | California disease, Desert rheumatism, San Joaquin valley fever, Valley fever |
| CURRENT STATUS: | in PDB |
| COMMUNITY REQUEST: | True |
| NIH RISK GROUP: | 2 |
| SELECT AGENT: | True |
| NIH PRIORITY pathogens category: |
II |
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Structures
5B8I
DEPOSITED: 5/3/2015
DETERMINATION: XRay
CLONE: CoimA.00174.a.GM11.GE00347
PROTEIN: CoimA.00174.a.GM11.PD00367
Publications by SSGCID
Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
Fox D, Hoy M, Juvvadi PR, Bobay B, Gobeil S, Venters R, Chang Z, Lin J, Averette A, Cole D, Barrington B, Wheaton J, Ciofani M, Trzoss M, Li X, Lee S, Chen Y, Mutz M, Spicer L, Schumacher M, Heitman J, Steinbach W
Nat Commun - 2019
volume 10, pages 4275
PMID: 31537789; PMCID: PMC6753081
External Resources
| RESOURCE | REFERENCE ID |
|---|---|
| EuPathDB: | FungiDB:CIMG_06667 |
| RefSeq: | XP_001243071.1 |
| UniProt: | J3K9C5 |
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols.
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AA Sequence
MDGSKIVRAV TEKKPVPEID FTLHTMEDGT QVSTLERVCK EVQAPAFHTP TNEQFWSPVD PSKPNLAFLK QHFYREGRLT EDQALWIIQA GTELLRAEPN LLEMDAPITV CGDVHGQYYD LMKLFEVGGD PAETRYLFLG DYVDRGYFSI ECVLYLWALK IWYPNTLWLL RGNHECRHLT DYFTFKLECK HKYSEKVYDA CMESFCALPL AAIMNKQFLC IHGGLSPELH TLEDIKSIDR FREPPTHGLM CDILWADPLE DFGTEKTGEY FVHNNVRGCS FFFSYPAACA FLEKNNLLSI IRAHEAQDAG YRMYQKTRTT GFPSVMTIFS APNYLDVYNN KAAVLKYENN VMNIRQFNCT PHPYWLPNFM DVFTWSLPFV GEKITDMLIA ILNTCSKEEL EEEPSAFSSA PASPPLPMDT DSAEFKRRAI KNKILAIGRL SRVFQVLREE SERVTELKTA SGGRLPAGTL MLGAEGIKQA IHNFEDARKV DLQNERLPPS QEEVMRKAEE DRRQALERAA QEAENDAGLA TVARRISMSS GSGRPRRKEA
NT Sequence
atggatgggt ccaaaattgt ccgggctgtc accgagaaga agcccgtccc tgagattgac ttcacactcc atactatgga agacgggacc caggtttcta ccctggagag agtctgcaaa gaggtgcaag ctcctgcatt tcacactcca acaaacgaac agttctggtc acctgtggat ccctccaagc ctaatctcgc atttctcaag caacatttct atcgcgaagg acgactcacc gaagatcaag cgctatggat catacaagca ggaacagaat tgctgcgtgc agagccaaat ctcctggaga tggatgctcc catcaccgtg tgtggcgacg tgcatggcca atattatgac ttgatgaaat tgtttgaagt tggaggagac ccagcagaga cacgatatct gttcctggga gactacgttg acagaggtta cttcagcatt gagtgcgtat tatatctatg ggctctaaag atctggtacc ctaatacact ctggttgctg cgcgggaatc atgaatgccg ccatctcact gactatttca cattcaaatt ggaatgcaaa cataaatact cagagaaagt gtatgatgca tgcatggagt cattttgtgc actccccttg gctgccatta tgaataaaca gttcctttgc attcacggtg gtctaagccc tgaactacat acgttggagg atataaaatc tattgatcgc ttcagagaac cacctactca tggattaatg tgcgacattc tctgggccga ccctcttgaa gattttggaa cggaaaagac gggggaatat tttgtccaca acaatgtccg aggatgttcc ttctttttct cttatccagc ggcctgtgca tttcttgaga aaaacaactt gttatcgata atccgcgccc acgaggccca agatgccggg tatagaatgt atcagaagac tcgcacaact ggctttccca gtgtcatgac tatcttcagc gctcctaatt acctcgacgt ttataacaac aaagccgcgg ttcttaagta tgaaaacaat gtaatgaaca tccgacagtt caactgcacg cctcacccgt actggctccc gaatttcatg gacgttttca cctggtcact gccatttgtt ggcgaaaaga ttactgacat gctaattgcc attctaaaca catgctcaaa ggaagagctc gaggaggaac cttcggcatt ttcttctgct ccagcatcgc cgcctcttcc aatggatact gacagtgcag agttcaagag acgcgcaatc aagaacaaga tccttgctat tgggcgtctg tctcgcgttt tccaggtttt gcgtgaagaa tccgaacgtg ttacggaatt aaagactgca tctgggggtc gtctgcctgc agggacgctc atgcttggcg cagaaggtat caaacaagcg attcataatt ttgaagatgc ccgtaaggtc gacctgcaaa acgagcgcct gccgccctca caggaagaag tgatgaggaa ggcggaagaa gatcgaagac aggccctaga gcgcgcggct caggaagcag agaatgacgc tggactcgct actgtggccc ggagaatcag catgtcctct ggctctggca gacctcgccg caaggaggca taa