ClboA.17807.a
Botulinum C/D mosaic neurotoxin (BoNT/C-D)
| CENTER ID: | ClboA.17807.a |
| ORGANISM: | Clostridium botulinum |
| ASSOCIATED DISEASE: | botulism |
| CURRENT STATUS: | in PDB |
| COMMUNITY REQUEST: | True |
| NIH RISK GROUP: | 2 |
| SELECT AGENT: | True |
| NIH PRIORITY pathogens category: |
II/IIIA/IIIB |
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Structures
3PME
DEPOSITED: 11/16/2010
DETERMINATION: XRay
CLONE: ClboA.17807.a.AV2.GE40869
PROTEIN: ClboA.17807.a.AV2.PB00046
4F83
DEPOSITED: 5/16/2012
DETERMINATION: XRay
CLONE: ClboA.17807.a.AV2.GE40869
PROTEIN: ClboA.17807.a.AV2.PB00046
Publications by SSGCID
Crystal structure of the receptor binding domain of the botulinum C-D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactions.
Buchko GW, Qin L, Robinson H, Varnum SM, Zhang Y
Biochem. Biophys. Res. Commun. - 2010
volume 404, issue 1, pages 407-12
PMID: 21130733; PMCID: PMC3019264
PDB:
3PME
Structural insights into the functional role of the Hcn sub-domain of the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/D.
Buchko GW, Edwards TE, Gardberg AS, Robinson H, Sankaran B, Varnum SM, Zhang Y
Biochimie - 2013
volume 95, issue 7, pages 1379-85
PMID: 23523511; PMCID: PMC3674139
PDB:
4F83
External Resources
| RESOURCE | REFERENCE ID |
|---|---|
| OrthoMCL: | OG5_216721 |
| PATRIC ID: | fig|929506.3.peg.94 |
| RefSeq: | WP_013720855.1 |
| UniProt: | Q9LBS7 |
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols.
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AA Sequence
MPITINNFNY SDPVDNKNIL YLDTHLNTLA NEPEKAFRII GNIWVIPDRF SRDSNPNLNK PPRVTSPKSG YYDPNYLSTD SEKDTFLKEI IKLFKRINSR EIGEELIYRL ATDIPFPGNN NTPINTFDFD VDFNSVDVKT RQGNNWVKTG SINPSVIITG PRENIIDPET STFKLTNNTF AAQEGFGALS IISISPRFML TYSNATNNVG EGRFSKSEFC MDPILILMHE LNHAMHNLYG IAIPNDQRIS SVTSNIFYSQ YKVKLEYAEI YAFGGPTIDL IPKSARKYFE EKALDYYRSI AKRLNSITTA NPSSFNKYIG EYKQKLIRKY RFVVESSGEV AVDRNKFAEL YKELTQIFTE FNYAKIYNVQ NRKIYLSNVY TPVTANILDD NVYDIQNGFN IPKSNLNVLF MGQNLSRNPA LRKVNPENML YLFTKFCHKA IDGRSLYNKT LDCRELLVKN TDLPFIGDIS DIKTDIFLSK DINEETEVID YPDNVSVDQV ILSKNTSEHG QLDLLYPIIE GESQVLPGEN QVFYDNRTQN VDYLNSYYYL ESQKLSDNVE DFTFTTSIEE ALDNSGKVYT YFPKLADKVN TGVQGGLFLM WANDVVEDFT TNILRKDTLD KISDVSAIIP YIGPALNISN SVRRGNFTEA FAVTGVTILL EAFQEFTIPA LGAFVIYSKV QERNEIIKTI DNCLEQRIKR WKDSYEWMIG TWLSRITTQF NNISYQMYDS LNYQADAIKD KIDLEYKKYS GSDKENIKSQ VENLKNSLDI KISEAMNNIN KFIRECSVTY LFKNMLPKVI DELNKFDLKT KTELINLIDS HNIILVGEVD RLKAKVNESF ENTIPFNIFS YTNNSLLKDI INEYFNSIND SKILSLQNKK NALVDTSGYN AEVRLEGDVQ VNTIYTNDFK LSSSGDKIIV NLNNNILYSA IYENSSVSFW IKISKDLTNS HNEYTIINSI KQNSGWKLCI RNGNIEWILQ DINRKYKSLI FDYSESLSHT GYTNKWFFVT ITNNIMGYMK LYINGELKQS ERIEDLNEVK LDKTIVFGID ENIDENQMLW IRDFNIFSKE LSNEDINIVY EGQILRNVIK DYWGNPLKFD TEYYIINDNY IDRYIAPKSN ILVLVQYPDR SKLYTGNPIT IKSVSDKNPY SRILNGDNIM FHMLYNSGKY MIIRDTDTIY AIEGRECSKN CVYALKLQSN LGNYGIGIFS IKNIVSQNKY CSQIFSSFMK NTMLLADIYK PWRFSFENAY TPVAVTNYET KLLSTSSFWK FISRDPGWVE
NT Sequence
atgccaataa caattaacaa ctttaattat tcagatcctg ttgataataa aaatatttta tatttagata ctcatttaaa tacattagct aatgagcctg aaaaagcctt tcgcattata gggaatatat gggtaatacc cgatagattt tcaagagatt ctaatccaaa tttaaataaa cctcctcgag ttacaagccc taaaagtggt tattatgatc ctaattattt gagtactgat tctgaaaaag atacattttt aaaagaaatt ataaagttat ttaaaagaat taactctaga gaaataggag aagaattaat atatagactt gcaacagaca taccctttcc tgggaataac aatactccaa ttaatacttt tgattttgat gtagatttta acagtgttga tgttaaaact agacaaggta acaactgggt taaaactggt agtataaatc ctagtgttat aataactgga cctagagaaa acattataga cccagaaact tctacgttta aattaactaa caatactttt gcggcacaag aaggatttgg tgctttatca ataatttcaa tatcacctag atttatgcta acatatagta atgcaactaa taatgtagga gagggtagat tttctaagtc tgaattttgc atggatccaa tactaatttt aatgcatgaa cttaatcatg caatgcataa tttatatgga atagctatac caaatgatca aagaatttca tctgtaacta gtaatatttt ttattctcaa tataaggtga aattagagta tgcagaaata tatgcatttg gaggtccaac tatagacctt attcctaaaa gtgcaaggaa atattttgag gaaaaggcat tggattatta tagatccata gctaaaagac ttaatagtat aactactgca aatccttcaa gctttaataa atatatagga gaatataaac agaaacttat tagaaagtat agattcgtag tagaatcttc aggtgaagtt gcagtagatc gtaataagtt tgctgagtta tataaagaac ttacacaaat atttacagaa tttaactacg ctaaaatata taatgtacaa aataggaaaa tatatctttc aaatgtatat actccggtta cggcaaatat attagacgat aatgtttatg atatacaaaa tggatttaac atacctaaaa gtaatttaaa tgtactattt atgggtcaaa atttatctcg aaatccagca ttaagaaaag tcaatcctga aaatatgctt tatttattta caaaattttg ccataaagca atagatggta gatcattata taataaaaca ttagattgta gagagctttt agttaaaaat actgacttac cctttatagg tgatattagt gatatcaaaa ctgatatatt tttaagcaaa gatattaatg aagaaactga agttatagac tatccggaca atgtttcagt ggatcaagtt attctcagta agaatacctc agaacatgga caactagatt tattataccc tattattgaa ggtgagagtc aagtattacc gggagagaat caagtctttt atgataatag aactcaaaat gttgattatt tgaattctta ttattaccta gaatctcaaa aactaagtga taatgttgaa gattttactt ttacgacatc aattgaggaa gctttggata atagtggaaa agtatatact tactttccta aactagctga taaagtaaat acgggtgttc aaggtggttt atttttaatg tgggcaaatg atgtagttga agattttact acaaatattc taagaaaaga tacattagat aaaatatcag atgtatcagc tattattccc tatataggac ctgcattaaa tataagtaat tctgtaagaa ggggaaattt tactgaagca tttgcagtta ccggtgtaac tattttatta gaagcgtttc aagaatttac aatacctgca cttggtgcat ttgtgattta tagtaaggtt caagaaagaa acgagattat taaaactata gataattgtt tagaacaaag gattaaaaga tggaaagatt catatgaatg gatgatagga acgtggttat ccaggattac tactcaattt aataatataa gttatcaaat gtatgattct ttaaattatc aggcagatgc aatcaaagat aaaatagatt tagaatataa aaaatactca ggaagtgata aagaaaatat aaaaagtcaa gttgaaaatt taaaaaatag tttagatata aaaatctcgg aagcaatgaa taatataaat aaatttatac gagaatgttc tgtaacatac ttatttaaaa atatgctccc taaagtaatt gatgaattaa ataagtttga tttaaaaact aaaacagaat taattaatct tatagatagt cataatatta ttctagttgg tgaagtagat agattaaaag caaaagtaaa tgagagtttt gaaaatacaa taccctttaa tattttttca tatactaata attctttatt aaaagatata attaatgaat atttcaatag tattaatgat tcaaaaattt tgagcttaca aaacaaaaaa aatgctttag tggatacatc aggatataat gcagaagtga ggctagaagg tgatgttcaa gttaatacga tatatacaaa tgattttaaa ttaagtagtt caggagataa aattatagta aatttaaata ataatatttt atatagcgct atttatgaga actctagtgt tagtttttgg attaagatat ctaaagattt aactaattct cataatgaat atacaataat taatagtata aaacaaaatt ctgggtggaa attatgtatt aggaatggca atatagaatg gattttacaa gatattaata gaaagtataa aagtttaatt tttgattata gtgaatcatt aagtcataca ggatatacaa ataaatggtt ttttgttact ataactaata atataatggg gtatatgaaa ctttatataa atggagaatt aaagcagagt gaaagaattg aagatttaaa tgaggttaag ttagataaaa ccatagtatt tggaatagat gagaatatag atgagaatca gatgctttgg attagagatt ttaatatttt ttctaaagaa ttaagcaatg aagatattaa tattgtatat gagggacaaa tattaagaaa tgttattaaa gattattggg gaaatccttt gaagtttgat acagaatatt atattattaa tgataattat atagataggt atatagcacc taaaagtaat atacttgtac ttgttcagta tccagataga tctaaattat atactggaaa tcctattact attaaatcag tatctgataa gaatccttat agtagaattt taaatggaga taatataatg tttcatatgt tatataatag tgggaaatat atgataataa gagatactga tacaatatat gcaatagaag gaagagagtg ttcaaaaaat tgtgtatatg cattaaaatt acagagtaat ttaggtaatt atggtatagg tatatttagt ataaaaaata ttgtatctca aaataaatat tgtagtcaaa ttttctctag ttttatgaaa aatacaatgc ttctagcaga tatatataaa ccttggagat tttcttttga aaatgcatac acgccagttg cagtaactaa ttatgagaca aaactattat caacttcatc tttttggaaa tttatttcta gggatccagg atgggtagag taa