ButhA.01187.a: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase) (GluRS) (BTH_I1984) (gltX)
Target Characteristics
| from organism: | Burkholderia thailandensis E264 |
| most recent status: | in PDB |
| center reference id: | ButhA.01187.a |
| is community request: | True |
| associated disease: | |
| NIH risk group: | 3 |
| is select agent: | False |
| NIH priority pathogens category: |
IIIB |
Ordering Clones & Proteins
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Clones*
| CENTER REFERENCE ID |
DOMAIN/REGION DESCRIPTION |
INFO | AA START |
AA STOP |
ORDER MATERIAL |
|---|---|---|---|---|---|
| ButhA.01187.a.A1.GE32759 | full length | 1 | 469 | GE32759 |
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information
using the button in the "info" column.
Structures
4G6Z
Deposited: 7/19/2012
Determination: XRay
Diffraction Image
Clone: ButhA.01187.a.A1.GE32759
Protein: ButhA.01187.a.A1.PS01190
Publications by SSGCID
Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms
Clifton MC, Dranow DM, Edwards TE, Lorimer DD, Manoil C, Moen S, Myler PJ, Sankaran B, Sharma A, Staker BL, Van Voorhis WC
Sci Rep - 2017
volume 7, issue 1, pages 223
PMID: 28303005; PMCID: PMC5428304
Combining functional and structural genomics to sample the essential Burkholderia structome.
Abendroth J, Armour B, Barrett L, Baugh L, Begley DW, Buchko GW, Choi R, Clifton MC, Dieterich SH, Dranow DM, Edwards TE, Fairman JW, Fox D, Gallagher LA, Gardberg AS, Gillespie A, Manoil C, Myler PJ, Nakazawa-Hewitt S, Napuli A, Nguyen MT, Patrapuvich R, Phan I, Stacy R, Staker BL, Stewart LJ, Van Voorhis WC
PLoS ONE - 2012
volume 8, issue 1, pages e53851
PMID: 23382856; PMCID: PMC3561365
PDB:
3D63,
3DAH,
3EIZ,
3EJ2,
3EK2,
3EZO,
3F0F,
3FTP,
3GK0,
3GK3,
3GVF,
3GWA,
3GWE,
3IML,
3SZ8,
3T4C,
3TML,
3TMQ,
3TXY,
3U7J,
3UE9,
3UK1,
3UK2,
3UND,
3UPT,
3URR,
3UW1,
3UW2,
3UW3,
3V2I,
3V7N,
3V8H,
3V9O,
3V9P,
3VAV,
4DDO,
4DFE,
4DHE,
4DHK,
4DUT,
4DZ4,
4E4T,
4E51,
4EFI,
4EG0,
4EGJ,
4EK2,
4EQY,
4EWG,
4EX5,
4EXQ,
4F2G,
4F32,
4F3N,
4F3Y,
4F4H,
4F7D,
4FK8,
4FRY,
4G1K,
4G67,
4G6Z,
4GHK,
4H3Y,
4H3Z,
4H4G
External Resources
| Resource | Reference ID |
|---|---|
| OrthoMCL: | OG5_127621 |
| PATRIC ID: | fig|271848.6.peg.4795 |
| RefSeq: | YP_442513.1 |
| UniProt: | Q2SX36 |
Enzyme & Pathway Information
| Pathway | Pathway ID | EC Number |
|---|---|---|
| adenosylcobalamin biosynthesis II (aerobic) | P381-PWY | 6.1.1.17 |
| tetrapyrrole biosynthesis I (from glutamate) | PWY-5188 | 6.1.1.17 |
| adenosylcobalamin biosynthesis I (anaerobic) | PWY-5507 | 6.1.1.17 |
| superpathay of heme b biosynthesis from glutamate | PWY-5918 | 6.1.1.17 |
| tRNA charging | TRNA-CHARGING-PWY | 6.1.1.17 |
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols.
To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MTRPVRTRFA PSPTGFIHLG NIRSALYPWA FARKMKGTFV LRIEDTDVER SSQEAVDAIL EGMAWLGLDY DEGPYYQMQR MDRYREVLAQ MQEKGLVYPC YMSTEELDAL RERQRAAGEK PRYDGTWRPE PGKVLPEPPA GVAPVLRFRN PLTGTVAWDD AVKGRVEISN EELDDLVVAR PDGTPMYNFC VVVDDLDMGI THVIRGDDHV NNTPRQINIL RALGGEVPVY AHLPTVLNEQ GEKMSKRHGA MSVMGYRDAG YLPEAVLNYL ARLGWSHGDA EIFTREQFVE WFDLEHLGKS PAQYDHNKLN WLNNHYIKEA DDARLAGLAK PFFAALGIDA GAIEQGPDLV SVMGLMKDRA STVKEIAENS AMFYRAPAPG ADALAQHVTD AVRPALVEFA AALKTVEWTK EAIAAALKAV LGAHKLKMPQ LAMPVRLLVA GTTHTPSIDA VLLLFGRDVV VSRIEAALA
NT Sequence
atgacccgtc ctgtacgcac ccgttttgcg ccgagcccca ccggcttcat ccatctcggc aacatccgat ccgcgcttta tccgtgggcg ttcgcccgca agatgaaggg cacgttcgtg ctgcggatcg aggacaccga tgtcgagcgt tcgagccagg aggcggtcga cgcgatcctc gaagggatgg cgtggctcgg cctcgattac gacgaaggcc cgtactatca gatgcagcgg atggatcgct atcgcgaagt gctcgcgcag atgcaggaga agggcctcgt ctacccgtgc tacatgtcga ccgaagagct cgacgcgttg cgcgagcgcc agcgcgcggc gggcgagaag ccgcgctacg acggcacgtg gcgcccggag ccgggcaagg tgctgcccga gccgcccgcc ggcgtcgcgc ccgtgctgcg cttccgcaat ccgctgacag gcacggtggc ctgggacgat gcggtgaagg gccgcgtcga gatctcgaac gaggaactcg acgatctcgt cgtcgcgcgt cccgacggca cgccgatgta caacttctgc gtcgtcgtcg acgatctcga catgggcatc acgcacgtga tccgcggcga cgaccacgtg aacaacacgc cgcgccagat caacatcctg cgcgcgctcg gcggcgaagt gccggtgtac gcgcacttgc cgaccgtgct caacgagcag ggcgagaaga tgagcaagcg tcacggcgcg atgagcgtga tgggctatcg cgatgccggc tatctgcctg aggcggtgct caactatctc gcgcgccttg gctggtcgca cggcgacgcg gagatcttca cgcgcgagca gttcgtcgaa tggttcgacc tcgagcatct cggcaagtcg cccgcgcagt acgaccataa caagctgaac tggttgaaca accattacat caaggaagcg gacgacgcgc gtctcgccgg gctggcgaag ccgttcttcg cggcgctcgg catcgacgcc ggcgcgatcg agcaggggcc ggacctcgta agcgtgatgg ggctgatgaa ggaccgcgcg tcgacggtga aggaaatcgc ggagaattcg gcgatgttct accgtgcgcc cgcgcccggc gcggatgcgc tcgcgcagca cgtgaccgac gcggtgcgtc cggcgctcgt ggagttcgcg gcggcgctga agacggtcga atggacgaag gaggcgatcg cggccgcgct gaaggccgtg ctcggtgcgc acaagctgaa gatgccgcag ctcgcgatgc cggtgcgcct gctcgtggcg ggcacgacgc acacgccgtc gatcgacgcg gtgctgctgc tgttcggccg cgacgtcgtc gtgtcgcgta tcgaggcggc gctcgcgtaa