BewuS.18655.a
Spike glycoprotein
| CENTER ID: | BewuS.18655.a |
| ORGANISM: | Betacoronavirus SARS-CoV-2 human/India/2022 [Omicron XBB.1] |
| ASSOCIATED DISEASE: | |
| CURRENT STATUS: | in PDB |
| COMMUNITY REQUEST: | False |
| NIH RISK GROUP: | 2 |
| SELECT AGENT: | False |
| NIH PRIORITY pathogens category: |
IIIC |
Ordering Clones & Proteins
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Structures
8FXB
DEPOSITED: 1/24/2023
DETERMINATION: CryoEM
CLONE: BewuS.18655.a.K11.GE45345
PROTEIN: BewuS.18655.a.K11.PE00073
9ATM
DEPOSITED: 2/27/2024
DETERMINATION: XRay
CLONE: BewuS.18655.a.ME21.GE45874
PROTEIN: BewuS.18655.a.ME21.PE00095
Publications by SSGCID
Neutralization, effector function and
immune imprinting of Omicron variants
Kim M, Veesler D, Park YJ, Cameroni E, Lanzavecchia A, Corti D, Dang HV, Chu H, Pinto D, Beltramello M, Culap K, Guarino B, Case JB, Snell G, Diamond M, Piccoli L, Czudnochowski N, Silacci-Fregni C, Bassi J, Biggiogero M, Ceschi A, Ferrari P, Garzoni C, Schmid M, Subramaniam S, Saliba Christian, Dellota E, Addetia A, Sprouse K, Giannini O, Lombardo G, Franko N, Logue J, Giurdanella M, Stewart C, Purcell LA, Scheaffer SM, Muoio F, Dini M, Vincenzetti L, Acosta R, Johnson D, Leoni G, McAlister C, Rajesh A, Whitener B, Franzetti-Pellanda A, Zappi S, Bernasconi L, Schnell G, Yoshiyama C
Nature - 2023
PMID: 37648855; PMCID: PMC10511321
A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification
Veesler D, Park YJ, Cameroni E, Lanzavecchia A, Corti D, Dang HV, Tortorici MA, Pinto D, Zatta F, De Marco A, Guarino B, Snell G, Telenti A, Starr T, Czudnochowski N, Rosen L, Lempp F, Benigni F, Liu Z, Zepeda S, di Iulio J, Subramaniam S, Saliba Christian, Dellota E, Addetia A, Whelan SPJ, Sprouse K, Zhang I, Noack J, Giurdanella M, Hauser K, Purcell LA, Acosta R, Rajesh A, Schnell G, de Melo GD, Kergoat L, Bourhy H, Lee J, Taylor AL, Brown J, Foreman WB, Bohan D, Errico JM, Chartron JW, Cusumano G, Tao Q, Schmid MA, Pizzuto MJ
Cell - 2024
volume 187, issue 25, pages 7196-7213
PMID: 39383863; PMCID: PMC11645210
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols.
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AA Sequence
MFVFLVLLPL VSSQCVNLIT RTQSYTNSFT RGVYYPDKVF RSSVLHSTQD LFLPFFSNVT WFHAIHVSGT NGTKRFDNPA LPFNDGVYFA STEKSNIIRG WIFGTTLDSK TQSLLIVNNA TNVVIKVCEF QFCNDPFLDV YQKNNKSWME SEFRVYSSAN NCTFEYVSQP FLMDLEGKEG NFKNLREFVF KNIDGYFKIY SKHTPINLER DLPQGFSALE PLVDLPIGIN ITRFQTLLAL HRSYLTPVDS SSGWTAGAAA YYVGYLQPRT FLLKYNENGT ITDAVDCALD PLSETKCTLK SFTVEKGIYQ TSNFRVQPTE SIVRFPNITN LCPFHEVFNA TTFASVYAWN RKRISNCVAD YSVIYNFAPF FAFKCYGVSP TKLNDLCFTN VYADSFVIRG NEVSQIAPGQ TGNIADYNYK LPDDFTGCVI AWNSNKLDSK PSGNYNYLYR LFRKSKLKPF ERDISTEIYQ AGNKPCNGVA GSNCYSPLQS YGFRPTYGVG HQPYRVVVLS FELLHAPATV CGPKKSTNLV KNKCVNFNFN GLTGTGVLTE SNKKFLPFQQ FGRDIADTTD AVRDPQTLEI LDITPCSFGG VSVITPGTNT SNQVAVLYQG VNCTEVPVAI HADQLTPTWR VYSTGSNVFQ TRAGCLIGAE YVNNSYECDI PIGAGICASY QTQTKSHGSA GSVASQSIIA YTMSLGAENS VAYSNNSIAI PTNFTISVTT EILPVSMTKT SVDCTMYICG DSTECSNLLL QYGSFCTQLK RALTGIAVEQ DKNTQEVFAQ VKQIYKTPPI KYFGGFNFSQ ILPDPSKPSK RSPIEDLLFN KVTLADAGFI KQYGDCLGDI AARDLICAQK FNGLTVLPPL LTDEMIAQYT SALLAGTITS GWTFGAGPAL QIPFPMQMAY RFNGIGVTQN VLYENQKLIA NQFNSAIGKI QDSLSSTPSA LGKLQDVVNH NAQALNTLVK QLSSKFGAIS SVLNDILSRL DPPEAEVQID RLITGRLQSL QTYVTQQLIR AAEIRASANL AATKMSECVL GQSKRVDFCG KGYHLMSFPQ SAPHGVVFLH VTYVPAQEKN FTTAPAICHD GKAHFPREGV FVSNGTHWFV TQRNFYEPQI ITTDNTFVSG NCDVVIGIVN NTVYDPLQPE LDSFKEELDK YFKNHTSPDV DLGDISGINA SVVNIQKEID RLNEVAKNLN ESLIDLQELG KYEQYIKWPW YIWLGFIAGL IAIVMVTIML CCMTSCCSCL KGCCSCGSCC KFDEDDSEPV LKGVKLHYT
NT Sequence
ATGTTCGTCT TCCTGGTCTT GCTCCCGCTG GTCAGTAGCC AGTGCGTGAA CCTGATCACG CGCACCCAGT CTTATACGAA CTCCTTCACA AGAGGCGTGT ATTACCCCGA CAAGGTATTC CGCTCCAGCG TGTTACATTC CACGCAGGAT TTGTTCCTGC CTTTTTTCTC CAACGTCACC TGGTTCCACG CCATTCACGT CTCAGGAACG AATGGTACCA AACGCTTTGA CAACCCCGCC CTGCCCTTCA ATGACGGCGT GTACTTCGCC TCTACCGAGA AGTCTAACAT TATCAGAGGC TGGATCTTCG GTACTACACT GGATTCCAAA ACCCAGTCAC TGCTTATCGT GAACAATGCT ACCAATGTCG TGATCAAGGT GTGCGAATTC CAATTTTGTA ACGACCCATT CCTAGATGTG TACCAGAAGA ATAACAAGTC GTGGATGGAG AGCGAGTTCC GCGTTTACAG TTCCGCTAAT AACTGTACAT TTGAGTACGT TAGCCAGCCT TTTCTCATGG ATCTGGAAGG CAAGGAAGGG AACTTCAAGA ACTTACGCGA GTTCGTGTTC AAGAACATCG ACGGCTACTT CAAAATCTAT TCCAAGCACA CCCCCATCAA CTTAGAGCGC GATCTGCCTC AAGGATTCAG CGCGCTAGAA CCCCTGGTGG ACCTCCCAAT CGGAATCAAC ATCACTCGTT TCCAAACATT GCTGGCCCTC CACAGATCCT ATCTGACTCC CGTTGATTCC AGTTCCGGGT GGACGGCGGG CGCAGCGGCC TACTATGTGG GCTATCTTCA ACCCAGGACC TTCCTCCTGA AGTACAACGA AAACGGAACT ATCACAGACG CCGTCGATTG CGCCTTGGAT CCCCTGTCCG AGACTAAGTG CACCCTGAAG TCTTTCACTG TCGAGAAAGG TATTTACCAG ACTTCCAACT TTCGCGTCCA GCCTACGGAA TCGATTGTGC GTTTTCCAAA CATTACTAAT TTGTGCCCTT TTCATGAAGT GTTCAACGCG ACCACGTTCG CTAGCGTTTA CGCCTGGAAC AGGAAGCGAA TCTCCAATTG TGTGGCAGAT TATTCTGTGA TTTATAATTT CGCCCCATTC TTTGCCTTCA AATGCTACGG AGTGTCTCCT ACCAAACTGA ACGACTTGTG TTTTACTAAC GTTTACGCGG ACTCTTTCGT GATCCGTGGC AACGAGGTGT CCCAGATCGC CCCAGGTCAG ACTGGGAACA TCGCTGATTA CAATTACAAG CTTCCTGATG ACTTCACCGG TTGTGTCATT GCCTGGAACT CTAACAAGCT GGATTCCAAG CCCAGTGGCA ACTACAATTA CCTGTACCGC CTCTTTCGCA AGTCCAAGCT GAAGCCGTTC GAGCGCGACA TTAGTACCGA AATCTACCAG GCCGGGAACA AGCCTTGCAA CGGCGTCGCC GGATCGAACT GTTATAGCCC CCTGCAGTCC TACGGCTTTC GTCCGACTTA CGGGGTGGGT CACCAGCCGT ACCGCGTCGT TGTCTTATCT TTTGAGCTTC TGCACGCTCC CGCCACTGTG TGCGGCCCAA AAAAGTCTAC TAATCTGGTG AAGAACAAGT GTGTGAACTT TAACTTCAAT GGACTCACCG GCACCGGCGT GTTAACTGAG AGCAACAAAA AGTTTCTGCC ATTCCAACAG TTTGGCCGCG ATATCGCCGA CACCACAGAC GCTGTCCGTG ACCCCCAGAC CCTTGAAATT TTGGACATTA CTCCCTGCTC CTTCGGGGGC GTGTCCGTTA TCACGCCAGG AACCAACACG TCTAACCAGG TCGCAGTGCT CTACCAGGGA GTGAACTGCA CCGAGGTCCC TGTGGCTATC CACGCCGATC AGCTGACACC GACCTGGCGC GTGTATAGCA CCGGCTCTAA CGTGTTCCAG ACCCGCGCCG GGTGCCTGAT CGGCGCAGAG TATGTGAATA ACAGTTACGA GTGTGACATC CCCATTGGAG CTGGAATTTG CGCCTCCTAC CAAACCCAGA CTAAGTCCCA CGGTTCCGCC GGTTCCGTCG CGAGCCAGAG CATCATTGCT TACACCATGT CTCTGGGCGC TGAAAATAGC GTGGCCTACT CGAACAATTC TATCGCCATC CCTACCAACT TTACTATCAG TGTTACAACC GAGATCCTGC CTGTGTCTAT GACCAAGACC TCCGTAGATT GCACCATGTA TATCTGCGGT GACTCCACAG AGTGCTCCAA TCTGTTGCTT CAGTATGGGA GTTTCTGCAC CCAGCTGAAG AGAGCCCTGA CCGGTATCGC CGTCGAGCAG GACAAAAACA CACAGGAAGT TTTCGCGCAG GTTAAGCAGA TCTACAAAAC CCCTCCCATC AAATACTTCG GAGGGTTCAA CTTCAGCCAG ATCCTACCCG ACCCTAGCAA GCCTTCTAAG AGGTCCCCTA TCGAAGACTT GCTCTTTAAC AAGGTCACCC TGGCCGACGC TGGCTTTATA AAGCAGTACG GCGATTGTCT TGGGGACATC GCTGCCCGCG ACCTGATCTG TGCCCAGAAG TTCAACGGAC TGACCGTTCT GCCCCCGCTG CTCACAGACG AAATGATCGC CCAGTATACC AGCGCATTGC TGGCCGGTAC CATCACTTCG GGCTGGACAT TCGGCGCTGG CCCTGCTCTC CAGATCCCCT TCCCGATGCA GATGGCATAC AGGTTCAATG GTATTGGTGT TACCCAGAAC GTGCTGTATG AGAATCAGAA ACTGATCGCA AACCAGTTCA ACTCTGCAAT CGGGAAAATC CAGGATAGCC TGTCTAGCAC TCCGAGCGCT CTGGGCAAGC TGCAAGACGT AGTTAACCAC AACGCACAGG CACTGAACAC CCTCGTCAAG CAGCTGTCCA GTAAATTCGG CGCTATCTCT AGCGTTCTAA ACGACATTCT CAGCCGCCTG GATCCCCCAG AAGCCGAGGT CCAAATCGAC CGCCTCATTA CTGGCCGGCT GCAGTCACTG CAGACTTACG TGACGCAACA GCTGATACGC GCCGCTGAGA TCCGTGCCTC CGCCAACCTG GCCGCGACGA AGATGAGTGA ATGTGTCCTG GGCCAGAGCA AGCGAGTCGA CTTTTGCGGT AAGGGATATC ACCTCATGAG CTTCCCACAG TCCGCTCCCC ACGGTGTGGT CTTCCTGCAC GTGACCTACG TGCCCGCTCA AGAAAAAAAC TTTACTACCG CACCTGCTAT CTGCCATGAT GGCAAGGCGC ACTTCCCCCG CGAAGGGGTG TTTGTGTCCA ACGGCACACA CTGGTTCGTC ACCCAAAGGA ACTTTTACGA ACCTCAGATT ATCACTACCG ACAACACCTT TGTGTCAGGA AACTGCGACG TGGTCATTGG CATTGTCAAT AACACAGTTT ACGATCCACT GCAGCCAGAG CTCGACTCCT TCAAGGAAGA GCTGGATAAG TATTTCAAGA ACCATACATC TCCTGATGTG GACCTCGGCG ATATCTCCGG AATTAACGCT TCCGTGGTCA ACATCCAGAA GGAAATAGAT CGCCTGAATG AGGTCGCCAA GAACTTGAAC GAAAGCTTGA TCGACCTGCA GGAGCTGGGT AAGTACGAAC AGTACATCAA GTGGCCTTGG TACATCTGGC TTGGCTTCAT CGCGGGACTG ATCGCCATCG TCATGGTGAC CATCATGTTG TGTTGCATGA CATCGTGTTG CTCATGTCTG AAGGGCTGCT GTTCTTGCGG CAGTTGCTGT AAGTTTGATG AGGACGATTC AGAGCCAGTT CTGAAGGGCG TGAAGCTTCA TTACACA