AlfeA.18655.a
Spike glycoprotein
| CENTER ID: | AlfeA.18655.a |
| ORGANISM: | Alphacoronavirus Feline infectious peritonitis virus strain 79-1146 |
| ASSOCIATED DISEASE: | |
| CURRENT STATUS: | in PDB |
| COMMUNITY REQUEST: | False |
| NIH RISK GROUP: | NA |
| SELECT AGENT: | False |
| NIH PRIORITY pathogens category: |
non-BEI |
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Structures
9DAZ
DEPOSITED: 8/23/2024
DETERMINATION: CryoEM
CLONE: AlfeA.18655.a.K4.GE46028
PROTEIN: AlfeA.18655.a.K4.PE00103
9DB0
DEPOSITED: 8/23/2024
DETERMINATION: CryoEM
CLONE: AlfeA.18655.a.K3.GE46027
PROTEIN: AlfeA.18655.a.K3.PE00104
9DB1
DEPOSITED: 8/23/2024
DETERMINATION: CryoEM
CLONE: AlfeA.18655.a.K2.GE46026
PROTEIN: AlfeA.18655.a.K2.PE00105
9DBE
DEPOSITED: 8/23/2024
DETERMINATION: CryoEM
CLONE: AlfeA.18655.a.K4.GE46028
PROTEIN: AlfeA.18655.a.K4.PE00103
Publications by SSGCID
Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics
Tortorici MA, Veesler D, King NP, Bloom J, Joshi A, Stewart C, Brown JT, Choi A, Lee J, Leaf EM, Treichel C, Gibson C, Willoughby I, Harari S, Tait-Burkard C, Whittaker GR
Nature - 2025
volume 645, pages 235–243
PMID: 40634609; PMCID: PMC12408340
External Resources
| RESOURCE | REFERENCE ID |
|---|---|
| UniProt: | P10033 |
Sequences
These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols.
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AA Sequence
MIVLVTCLLL LCSYHTVLST TNNECIQVNV TQLAGNENLI RDFLFSNFKE EGSVVVGGYY PTEVWYNCSR TARTTAFQYF NNIHAFYFVM EAMENSTGNA RGKPLLFHVH GEPVSVIISA YRDDVQQRPL LKHGLVCITK NRHINYEQFT SNQWNSTCTG ADRKIPFSVI PTDNGTKIYG LEWNDDFVTA YISGRSYHLN INTNWFNNVT LLYSRSSTAT WEYSAAYAYQ GVSNFTYYKL NNTNGLKTYE LCEDYEHCTG YATNVFAPTS GGYIPDGFSF NNWFLLTNSS TFVSGRFVTN QPLLINCLWP VPSFGVAAQE FCFEGAQFSQ CNGVSLNNTV DVIRFNLNFT ADVQSGMGAT VFSLNTTGGV ILEISCYSDT VSESSSYSYG EIPFGITDGP RYCYVLYNGT ALKYLGTLPP SVKEIAISKW GHFYINGYNF FSTFPIGCIS FNLTTGVSGA FWTIAYTSYT EALVQVENTA IKNVTYCNSH INNIKCSQLT ANLNNGFYPV ASSEVGFVNK SVVLLPSFFT YTAVNITIDL GMKLSGYGQP IASTLSNITL PMQDNNTDVY CIRSNQFSVY VHSTCKSSLW DNIFNQDCTD VLEATAVIKT GTCPFSFDKL NNYLTFNKFC LSLSPVGANC KFDVAARTRT NEQVVRSLYV IYEEGDNIVG VPSDNSGLHD LSVLHLDSCT DYNIYGRTGV GIIRRTNSTL LSGLYYTSLS GDLLGFKNVS DGVIYSVTPC DVSAQAAVID GAIVGAMTSI NSELLGLTHW TTTPNFYYYS IYNYTSERTR GTAIDSNDVD CEPVITYSNI GVCKNGALVF INVTHSDGDV QPISTGNVTI PTNFTISVQV EYMQVYTTPV SIDCARYVCN GNPRCNKLLT QYVSACQTIE QALAMGARLE NMEVDSMLFV SENALKLASV EAFNSTENLD PIYKEWPSIG GSWLGGLKDI LPSHNSKRKY GSAIEDLLFD KVVTSGLGTV DEDYKRCTGG YDIADLVCAQ YYNGIMVLPG VANADKMTMY TASLAGGITL GALGGGAVAI PFAVAVQARL NYVALQTDVL NKNQQILANA FNQAIGNITQ AFGKVNDAIH QTSQGLATVA KALAKVQDVV NTQGQALSHL TVQLQNNFQA ISSSISDIYN RLDELSADAQ VDRLITGRLT ALNAFVSQTL TRQAEVRASR QLAKDKVNEC VRSQSQRFGF CGNGTHLFSL ANAAPNGMIF FHTVLLPTAY ETVTAWSGIC ASDGDRTFGL VVKDVQLTLF RNLDDKFYLT PRTMYQPRVA TSSDFVQIEG CDVLFVNATV IDLPSIIPDY IDINQTVQDI LENYRPNWTV PEFTLDIFNA TYLNLTGEID DLEFRSEKLH NTTVELAILI DNINNTLVNL EWLNRIETYV KWPWYVWLLI GLVVVFCIPL LLFCCFSTGC CGCIGCLGSC CHSICSRRQF ENYEPIEKVH VH
NT Sequence
ATGATTGTGC TCGTAACTTG CCTCTTGTTG TTATGTTCAT ACCACACAGT TTTGAGTACA ACAAATAATG AATGCATACA AGTTAACGTA ACACAATTGG CTGGCAATGA AAACCTTATC AGAGATTTTC TGTTTAGTAA CTTTAAAGAA GAAGGAAGTG TAGTTGTTGG TGGTTATTAC CCTACAGAGG TGTGGTACAA CTGCTCTAGA ACAGCTCGAA CTACTGCCTT TCAGTATTTT AATAATATAC ATGCCTTTTA TTTTGTTATG GAAGCCATGG AAAATAGCAC TGGTAATGCA CGTGGTAAAC CATTATTATT TCATGTGCAT GGTGAGCCTG TTAGTGTTAT TATATCGGCT TATAGGGATG ATGTGCAACA AAGGCCCCTT TTAAAACATG GGTTAGTGTG CATAACTAAA AATCGCCATA TTAACTATGA ACAATTCACC TCCAACCAGT GGAATTCCAC ATGTACGGGT GCTGACAGAA AAATTCCTTT CTCTGTCATA CCCACGGACA ATGGAACAAA AATCTATGGT CTTGAGTGGA ATGATGACTT TGTTACAGCT TATATTAGTG GTCGTTCTTA TCACTTGAAC ATCAATACTA ATTGGTTTAA CAATGTCACA CTTTTGTATT CACGCTCAAG CACTGCTACC TGGGAATACA GTGCTGCATA TGCTTACCAA GGTGTTTCTA ACTTCACTTA TTACAAGTTA AATAACACCA ATGGTCTAAA AACCTATGAA TTATGTGAAG ATTATGAACA TTGCACTGGC TATGCTACCA ATGTATTTGC TCCGACATCA GGTGGTTACA TACCTGATGG ATTTAGTTTT AACAATTGGT TCTTGCTTAC AAATAGTTCC ACTTTTGTTA GTGGCAGGTT TGTAACAAAT CAACCATTAT TGATTAATTG CTTGTGGCCA GTGCCCAGTT TTGGTGTAGC AGCACAAGAA TTTTGTTTTG AAGGTGCACA GTTTAGCCAA TGTAATGGTG TGTCTTTAAA TAACACAGTG GATGTTATTA GATTCAACCT TAATTTCACT GCAGATGTAC AATCTGGTAT GGGTGCTACA GTATTTTCAC TGAATACAAC AGGTGGTGTC ATTCTTGAAA TTTCATGTTA TAGTGACACA GTGAGTGAGT CTAGTTCTTA CAGTTATGGT GAAATCCCGT TCGGCATAAC TGACGGACCA CGATACTGTT ATGTACTTTA CAATGGCACA GCTCTTAAAT ATTTAGGAAC ATTACCACCC AGTGTAAAGG AAATTGCTAT TAGTAAGTGG GGCCATTTTT ATATTAATGG TTACAATTTC TTTAGCACAT TTCCTATTGG TTGTATATCT TTTAATTTAA CCACTGGTGT TAGTGGAGCT TTTTGGACAA TTGCTTACAC ATCGTATACT GAAGCATTAG TACAAGTTGA AAACACAGCT ATTAAAAATG TGACGTATTG TAACAGTCAC ATTAATAACA TTAAATGTTC TCAACTTACT GCTAATTTGA ATAATGGATT TTATCCTGTT GCTTCAAGTG AAGTAGGTTT CGTTAATAAG AGTGTTGTGT TATTACCTAG CTTTTTCACA TACACCGCTG TCAATATAAC CATTGATCTT GGTATGAAGC TTAGTGGTTA TGGTCAACCC ATAGCCTCGA CACTAAGTAA CATCACACTA CCAATGCAGG ATAACAATAC TGATGTGTAC TGTATTCGTT CTAACCAATT CTCAGTTTAT GTTCATTCCA CTTGCAAAAG TTCTTTATGG GACAATATTT TTAATCAAGA CTGCACGGAT GTTTTAGAGG CTACAGCTGT TATAAAAACT GGTACTTGTC CTTTCTCATT TGATAAATTG AACAATTACT TGACTTTTAA CAAGTTCTGT TTGTCGTTGA GTCCTGTTGG TGCTAATTGC AAGTTTGATG TTGCTGCACG TACAAGAACC AATGAGCAGG TTGTTAGAAG TCTATATGTA ATATATGAAG AAGGAGACAA CATAGTGGGT GTACCGTCTG ATAATAGCGG TCTGCACGAT TTGTCTGTGC TACACCTAGA CTCCTGTACA GATTACAATA TATATGGTAG AACTGGTGTT GGTATTATTA GACGAACTAA CAGTACGCTA CTTAGTGGCT TATATTACAC ATCACTATCA GGTGATTTGT TAGGCTTTAA AAATGTTAGT GATGGTGTCA TTTATTCTGT GACGCCATGT GATGTAAGCG CACAAGCGGC TGTTATTGAT GGTGCCATAG TTGGAGCTAT GACTTCCATT AACAGTGAAC TGTTAGGTCT AACACATTGG ACAACGACAC CTAATTTTTA TTACTACTCT ATATATAATT ACACAAGTGA GAGGACTCGT GGCACTGCAA TTGACAGTAA CGATGTTGAT TGTGAACCTG TCATAACCTA TTCTAATATA GGTGTTTGTA AAAATGGTGC TTTGGTTTTT ATTAACGTCA CACATTCTGA CGGAGACGTG CAACCAATTA GCACTGGTAA TGTCACGATA CCTACAAATT TTACTATATC TGTGCAAGTT GAATACATGC AGGTTTACAC TACACCAGTA TCAATAGATT GTGCAAGATA CGTTTGTAAT GGTAACCCTA GATGTAACAA ATTGTTAACA CAATATGTGT CTGCATGTCA AACTATTGAA CAAGCACTTG CAATGGGTGC CAGACTTGAA AACATGGAGG TTGATTCCAT GTTGTTTGTC TCGGAAAATG CCCTTAAATT GGCATCTGTT GAGGCGTTCA ATAGTACAGA AAATTTAGAT CCTATTTACA AAGAATGGCC TAGCATAGGT GGTTCTTGGC TAGGAGGTCT AAAAGATATA CTACCGTCCC ATAATAGCAA ACGTAAGTAT GGTTCTGCTA TAGAAGATTT GCTTTTTGAT AAAGTTGTAA CATCTGGTTT AGGTACAGTT GATGAAGATT ATAAACGTTG TACTGGTGGT TACGACATAG CAGACTTGGT GTGTGCTCAA TATTACAATG GCATCATGGT TCTACCAGGT GTAGCTAATG CTGACAAGAT GACTATGTAC ACAGCATCAC TTGCAGGTGG TATAACATTA GGTGCACTTG GTGGTGGCGC CGTGGCTATA CCTTTTGCAG TAGCAGTACA GGCTAGACTT AATTATGTTG CTCTACAAAC TGATGTATTG AATAAAAACC AACAGATCCT GGCTAATGCT TTCAATCAAG CTATTGGTAA CATTACACAG GCTTTTGGTA AGGTTAATGA TGCTATACAT CAAACATCAC AAGGTCTTGC CACTGTTGCT AAAGCGTTGG CAAAAGTGCA AGATGTTGTC AACACACAAG GGCAAGCTTT AAGTCACCTT ACAGTACAAT TGCAAAATAA TTTTCAAGCC ATTAGTAGTT CTATTAGTGA TATTTATAAC AGGCTTGACG AACTGAGTGC TGATGCACAA GTTGATAGGC TGATTACAGG TAGACTTACA GCACTTAATG CATTTGTGTC TCAGACTCTA ACCAGACAAG CAGAGGTTAG GGCTAGTAGA CAACTTGCCA AAGACAAGGT TAATGAATGT GTTAGGTCTC AGTCTCAGAG ATTCGGATTC TGTGGTAATG GTACACATTT GTTTTCACTA GCAAATGCAG CACCAAATGG CATGATTTTC TTTCATACAG TACTATTACC AACAGCTTAT GAAACTGTAA CAGCTTGGTC AGGTATTTGT GCTTCAGATG GCGATCGCAC TTTCGGACTT GTCGTTAAAG ATGTGCAGTT GACGTTGTTT CGTAATCTAG ATGACAAGTT CTATTTGACC CCCAGAACTA TGTATCAGCC TAGAGTTGCA ACTAGTTCTG ATTTTGTTCA AATTGAAGGG TGTGATGTGT TGTTTGTCAA CGCGACTGTA ATTGATTTGC CTAGTATTAT ACCTGACTAT ATTGACATTA ATCAAACTGT TCAAGACATA TTAGAAAATT ACAGACCAAA CTGGACTGTA CCTGAATTTA CACTTGATAT TTTCAACGCA ACCTATTTAA ATCTGACTGG TGAAATTGAT GACTTAGAGT TTAGGTCAGA AAAGCTACAT AACACTACAG TAGAACTTGC CATTCTCATT GATAACATTA ATAATACATT AGTCAATCTT GAATGGCTCA ATAGAATTGA AACTTATGTA AAATGGCCTT GGTATGTGTG GCTACTGATA GGTTTAGTAG TAGTATTTTG CATACCATTA CTGCTATTTT GCTGTTTTAG CACAGGTTGT TGTGGATGCA TAGGTTGTTT AGGAAGTTGT TGTCACTCTA TATGTAGTAG AAGACAATTT GAAAATTATG AACCAATTGA AAAAGTGCAT GTCCAC